Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T96215 Target Info
Target Name Plasmodium Glutamate dehydrogenase (Malaria gdh)
Synonyms
Glutamate dehydrogenase
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Target Type Successful Target
Gene Name Malaria gdh
Biochemical Class CH-NH(2) donor oxidoreductase
UniProt ID
Q9NGT0_PLAFA
Co-Targets of This Target  Top
Co-Target Name Estrogen receptor beta (ESR2) Successful Target
UniProt ID ESR2_HUMAN
Gene Name ESR2
Synonyms
Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; Erbeta; ESTRB; ER-beta; Beta-1
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Representative Drug(s) Hexachlorophene Drug Info IC50 = 98.27 nM [1]
Co-Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target
UniProt ID PGH2_HUMAN
Gene Name PTGS2
Synonyms
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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Representative Drug(s) Hexachlorophene Drug Info IC50 = 644.3 nM [2]
Co-Target Name Epidermal growth factor receptor (EGFR) Successful Target
UniProt ID EGFR_HUMAN
Gene Name EGFR
Synonyms
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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Representative Drug(s) Hexachlorophene Drug Info IC50 = 748.6 nM [2]
Co-Target Name Adenosine A2a receptor (ADORA2A) Successful Target
UniProt ID AA2AR_HUMAN
Gene Name ADORA2A
Synonyms
Adenosine receptor A2a; ADORA2; A2a Adenosine receptor; A(2A) adenosine receptor
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Representative Drug(s) Hexachlorophene Drug Info Ki = 906 nM [2]
Co-Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target
UniProt ID MK14_HUMAN
Gene Name MAPK14
Synonyms
SAPK2A; P38 mitogen activatedprotein kinase; P38 Mitogen-activatedprotein kinase alpha; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MXI2; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
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Representative Drug(s) Hexachlorophene Drug Info IC50 = 87.6 nM [2]
Co-Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target
UniProt ID MK01_HUMAN
Gene Name MAPK1
Synonyms
PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
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Representative Drug(s) Hexachlorophene Drug Info IC50 = 196 nM [2]
Co-Target Name Adenosine A3 receptor (ADORA3) Clinical trial Target
UniProt ID AA3R_HUMAN
Gene Name ADORA3
Synonyms
Adenosine receptor A3A; Adenosine receptor A3; Adenosine 3 receptor; A3AR; A3 Adenosine receptor
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Representative Drug(s) Hexachlorophene Drug Info Ki = 361.1 nM [2]
References  Top
REF 1 PubChem BioAssay: 2017 update. Nucleic Acids Res. 2017 Jan 4;45(D1):D955-D963.
REF 2 DrugMatrix in vitro pharmacology data. National Toxicology Program

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