Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T95385 Target Info
Target Name Interleukin-12 beta (IL12B)
Synonyms
NKSF2; NK cell stimulatory factor chain 2; Interleukin12 subunit beta; Interleukin-12 subunit beta; IL12 subunit p40; IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40
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Target Type Successful Target
Gene Name IL12B
Biochemical Class Cytokine: interleukin
UniProt ID
IL12B_HUMAN
Co-Targets of This Target  Top
Co-Target Name Adrenergic receptor beta-1 (ADRB1) Successful Target
UniProt ID ADRB1_HUMAN
Gene Name ADRB1
Synonyms
Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
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Representative Drug(s) Isoproterenol Drug Info EC50 = 0.084 nM [1]
Co-Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target
UniProt ID ADRB2_HUMAN
Gene Name ADRB2
Synonyms
Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
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Representative Drug(s) Isoproterenol Drug Info EC50 = 0.1585 nM [2]
Co-Target Name Adrenergic receptor beta-3 (ADRB3) Successful Target
UniProt ID ADRB3_HUMAN
Gene Name ADRB3
Synonyms
Beta3AR; Beta3-AR; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; Beta-3 adrenergic receptor; B3AR; ADRB3R
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Representative Drug(s) Isoproterenol Drug Info EC50 = 0.97 nM [1]
Co-Target Name HUAMN alpha-1 adrenergic receptor (ADRA1) Literature-reported Target
UniProt ID ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN
Gene Name ADRA1A; ADRA1B; ADRA1D
Synonyms
Alpha-1 adrenoreceptor
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Representative Drug(s) Isoproterenol Drug Info EC50 = 1.5 nM [3]
Co-Target Name HUMAN beta adrenergic receptor (BAR) Literature-reported Target
UniProt ID ADRB1_HUMAN; ADRB2_HUMAN; ADRB3_HUMAN
Gene Name ADRB1; ADRB2; ADRB3
Synonyms
Beta adrenoreceptor
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Representative Drug(s) Isoproterenol Drug Info EC50 = 30 nM [4]
References  Top
REF 1 Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I. J Med Chem. 2008 Mar 27;51(6):1925-44.
REF 2 Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists. J Med Chem. 2006 May 4;49(9):2758-71.
REF 3 Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem. 1992 Aug 7;35(16):3081-4.
REF 4 Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols. J Med Chem. 1982 Jun;25(6):680-4.

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