Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T94444 Target Info
Target Name Aldehyde oxidase (AOX1)
Synonyms
AOX1
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Target Type Successful Target
Gene Name AOX1
Biochemical Class Aldehyde/oxo donor oxidoreductase
UniProt ID
AOXA_HUMAN
Co-Targets of This Target  Top
Co-Target Name Indoleamine 2,3-dioxygenase 1 (IDO1) Successful Target
UniProt ID I23O1_HUMAN
Gene Name IDO1
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Representative Drug(s) Menadione Drug Info IC50 = 370 nM [1]
Co-Target Name Monoamine oxidase type B (MAO-B) Successful Target
UniProt ID AOFB_HUMAN
Gene Name MAOB
Synonyms
MAO-B; Amine oxidase [flavin-containing] B
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Representative Drug(s) Menadione Drug Info Ki = 400 nM [2]
Co-Target Name Thiosulfate sulfurtransferase (TST) Co-Target
UniProt ID THTR_HUMAN
Gene Name TST
Synonyms
Rhodanese
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Representative Drug(s) Menadione Drug Info IC50 = 1000 nM [3]
References  Top
REF 1 Polyketides and Anthranilic Acid Possessing 6-Deoxy-alpha-l-talopyranose from a Streptomyces Species. J Nat Prod. 2017 May 26;80(5):1378-86.
REF 2 Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorg Med Chem. 2011 Dec 15;19(24):7416-24.
REF 3 HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1;29(9):1106-1112.

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