Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93788 | Target Info | |||
| Target Name | Glucose-dependent insulinotropic receptor (GPR119) | ||||
| Synonyms |
GPR119; G-protein coupled receptor 119
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| Target Type | Successful Target | ||||
| Gene Name | GPR119 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Dipeptidyl peptidase 4 (DPP-4) | Successful Target | ||||
| UniProt ID | DPP4_HUMAN | |||||
| Gene Name | DPP4 | |||||
| Synonyms |
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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| Representative Drug(s) | Sitagliptin | Drug Info | IC50 = 3.5 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
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