Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92828 | Target Info | |||
| Target Name | Endothelin B receptor (EDNRB) | ||||
| Synonyms |
Endothelin receptor type B; Endothelin receptor Non-selective type; Endothelin receptor B; ETRB; ET-BR; ET-B
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | EDNRB | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Endothelin A receptor (EDNRA) | Successful Target | ||||
| UniProt ID | EDNRA_HUMAN | |||||
| Gene Name | EDNRA | |||||
| Synonyms |
HET-AR; Endothelin-1 receptor; Endothelin receptor type A; Endothelin receptor A; ETRA; ETA-R; ETA receptor; ETA; ET-A
Click to Show/Hide
|
|||||
| Representative Drug(s) | Macitentan | Drug Info | IC50 = 0.5 nM | Click to Show More | [1] | |
| 2 | Bosentan | Drug Info | IC50 = 4.7 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist. J Med Chem. 2012 Sep 13;55(17):7849-61. | ||||
| REF 2 | Metabolism study and biological evaluation of bosentan derivatives. Eur J Med Chem. 2016 Oct 4;121:658-670. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.