Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91451 | Target Info | |||
| Target Name | E2 ubiquitin-conjugating enzyme T (UBE2T) | ||||
| Synonyms |
Ubiquitin-protein ligase T; Ubiquitin carrier protein T; Cell proliferation-inducing gene 50 protein
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| Target Type | Clinical trial Target | ||||
| Gene Name | UBE2T | ||||
| Biochemical Class | Ubiquitin-conjugating enzyme family | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | Clinical trial Target | ||||
| UniProt ID | AKT1_HUMAN | |||||
| Gene Name | AKT1 | |||||
| Synonyms |
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
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| Representative Drug(s) | MK-2206 | Drug Info | IC50 = 8 nM | [1] | ||
| Co-Target Name | RAC-gamma serine/threonine-protein kinase (AKT3) | Clinical trial Target | ||||
| UniProt ID | AKT3_HUMAN | |||||
| Gene Name | AKT3 | |||||
| Synonyms |
STK-2; RAC-PK-gamma; Protein kinase B gamma; Protein kinase Akt-3; PKBG; PKB gamma
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| Representative Drug(s) | MK-2206 | Drug Info | IC50 = 65 nM | [1] | ||
| Co-Target Name | RAC-beta serine/threonine-protein kinase (AKT2) | Literature-reported Target | ||||
| UniProt ID | AKT2_HUMAN | |||||
| Gene Name | AKT2 | |||||
| Synonyms |
RAC-PK-beta; Protein kinase B beta; Protein kinase Akt-2; PKB beta
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| Representative Drug(s) | MK-2206 | Drug Info | IC50 = 12 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selectively nonselective kinase inhibition: striking the right balance. J Med Chem. 2010 Feb 25;53(4):1413-37. | ||||
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