Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T90985 Target Info
Target Name Bromodomain testis-specific protein (BRDT)
Synonyms
Cancer/testis antigen 9; CT9
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Target Type Clinical trial Target
Gene Name BRDT
Biochemical Class Bromodomain
UniProt ID
BRDT_HUMAN
Co-Targets of This Target  Top
Co-Target Name Bromodomain-containing protein 4 (BRD4) Clinical trial Target
UniProt ID BRD4_HUMAN
Gene Name BRD4
Synonyms
Protein HUNK1; HUNK1
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Representative Drug(s) (+)-JQ1 Drug Info Ki = 5.3 nM [1]
Co-Target Name Bromodomain-containing protein 3 (BRD3) Clinical trial Target
UniProt ID BRD3_HUMAN
Gene Name BRD3
Synonyms
RING3like protein; RING3L; RING3-like protein; KIAA0043
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Representative Drug(s) (+)-JQ1 Drug Info Ki = 6.6 nM [2]
Co-Target Name Bromodomain-containing protein 2 (BRD2) Clinical trial Target
UniProt ID BRD2_HUMAN
Gene Name BRD2
Synonyms
Really interesting new gene 3 protein; RING3; O27.1.1; KIAA9001
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Representative Drug(s) (+)-JQ1 Drug Info Ki = 12.5 nM [2]
References  Top
REF 1 Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
REF 2 Structure-Based Design of -Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem. 2015 Jun 25;58(12):4927-39.

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