Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90648 | Target Info | |||
| Target Name | B-Raf messenger RNA (BRAF mRNA) | ||||
| Synonyms |
V-Raf murine sarcoma viral oncogene homolog B1 (mRNA); Serine/threonine-protein kinase B-raf (mRNA); RAFB1 (mRNA); Proto-oncogene B-Raf (mRNA); P94 (mRNA); BRAF1 (mRNA); BRAF(V599E) (mRNA); BRAF serine/threonine kinase (mRNA); B-raf protein (mRNA); B-Raf (mRNA)
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | BRAF | ||||
| Biochemical Class | mRNA target | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | ||||
| UniProt ID | RAF1_HUMAN | |||||
| Gene Name | RAF1 | |||||
| Synonyms |
cRaf; Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF
Click to Show/Hide
|
|||||
| Representative Drug(s) | PLX-4720 | Drug Info | Ki = 3.3 nM | [1] | ||
| Co-Target Name | Pirin (PIR) | Co-Target | ||||
| UniProt ID | PIR_HUMAN | |||||
| Gene Name | PIR | |||||
| Synonyms |
Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase
Click to Show/Hide
|
|||||
| Representative Drug(s) | PLX-4720 | Drug Info | IC50 = 670 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41. | ||||
| REF 2 | Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett. 2018 Nov 16;9(12):1199-1204. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.