Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90038 | Target Info | |||
| Target Name | HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) | ||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | HMG-CoA reductase (HMGCR) | Successful Target | ||||
| UniProt ID | HMDH_HUMAN | |||||
| Gene Name | HMGCR | |||||
| Synonyms |
3-hydroxy-3-methylglutaryl-coenzyme A reductase
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| Representative Drug(s) | Atorvastatin | Drug Info | IC50 = 6 nM | [1] | ||
| Co-Target Name | Liver organic anion transporter 1 (SLCO1B1) | Literature-reported Target | ||||
| UniProt ID | SO1B1_HUMAN | |||||
| Gene Name | SLCO1B1 | |||||
| Synonyms |
Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; SLC21A6; OATPC; OATP2; OATP-C; OATP-2; Liver-specific organic anion transporter 1; LST1; LST-1
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| Representative Drug(s) | Atorvastatin | Drug Info | IC50 = 600 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparativemolecular similarity indices analysis (CoMSIA). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1027-32. | ||||
| REF 2 | The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery. Drug Metab Dispos. 2012 Aug;40(8):1641-8. | ||||
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