Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T89697 Target Info
Target Name Indoleamine 2,3-dioxygenase 1 (IDO1)
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase; INDO; IDO-1; IDO
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Target Type Successful Target
Gene Name IDO1
Biochemical Class Oxygenase
UniProt ID
I23O1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Tryptophan 2,3-dioxygenase (TDO) Patented-recorded Target
UniProt ID T23O_HUMAN
Gene Name TDO2
Synonyms
Tryptophanase; Tryptophan pyrrolase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO; TO
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Representative Drug(s) INCB24360 Drug Info IC50 = 242 nM [1]
Co-Target Name Indoleamine 2,3-dioxygenase 2 (IDO2) Patented-recorded Target
UniProt ID I23O2_HUMAN
Gene Name IDO2
Synonyms
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; Indoleamine 2,3-dioxygenase-like protein 1; INDOL1; IDO-2
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Representative Drug(s) INCB24360 Drug Info IC50 = 710 nM [2]
References  Top
REF 1 Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives. Eur J Med Chem. 2018 Dec 5;160:133-145.
REF 2 Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer. Eur J Med Chem. 2019 Nov 15;182:111629.

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