Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T89041 Target Info
Target Name Steroid 17-alpha-monooxygenase (S17AH)
Synonyms
Steroid 17-alpha-hydroxylase/17,20 lyase; P450c17; P450-C17; P450 17; CYPXVII; CYP17A1; CYP 17; 17 alpha-Hydroxylase/C17-20-lyase
    Click to Show/Hide
Target Type Successful Target
Gene Name CYP17A1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
CP17A_HUMAN
Co-Targets of This Target  Top
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
    Click to Show/Hide
Representative Drug(s) ABIRATERONE Drug Info IC50 = 230 nM [1]
Co-Target Name Cytochrome P450 21 (CYP21A2) Co-Target
UniProt ID CP21A_HUMAN
Gene Name CYP21A2
Synonyms
Steroid 21-hydroxylase; 21-OHase; Cytochrome P-450c21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B
    Click to Show/Hide
Representative Drug(s) ABIRATERONE Drug Info IC50 = 32.4 nM [1]
References  Top
REF 1 Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2. J Med Chem. 2018 Jun 14;61(11):4946-60.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.