Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T89041 | Target Info | |||
Target Name | Steroid 17-alpha-monooxygenase (S17AH) | ||||
Synonyms |
Steroid 17-alpha-hydroxylase/17,20 lyase; P450c17; P450-C17; P450 17; CYPXVII; CYP17A1; CYP 17; 17 alpha-Hydroxylase/C17-20-lyase
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Target Type | Successful Target | ||||
Gene Name | CYP17A1 | ||||
Biochemical Class | Paired donor oxygen oxidoreductase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Albendazole monooxygenase (CYP3A4) | Clinical trial Target | ||||
UniProt ID | CP3A4_HUMAN | |||||
Gene Name | CYP3A4 | |||||
Synonyms |
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) | ABIRATERONE | Drug Info | IC50 = 230 nM | [1] | ||
Co-Target Name | Cytochrome P450 21 (CYP21A2) | Co-Target | ||||
UniProt ID | CP21A_HUMAN | |||||
Gene Name | CYP21A2 | |||||
Synonyms |
Steroid 21-hydroxylase; 21-OHase; Cytochrome P-450c21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B
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Representative Drug(s) | ABIRATERONE | Drug Info | IC50 = 32.4 nM | [1] |
References | Top | ||||
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REF 1 | Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2. J Med Chem. 2018 Jun 14;61(11):4946-60. |
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