Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T89034 Target Info
Target Name Plasminogen (PLG)
Synonyms
Plasmin
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Target Type Successful Target
Gene Name PLG
Biochemical Class Peptidase
UniProt ID
PLMN_HUMAN
Co-Targets of This Target  Top
Co-Target Name Coagulation factor IIa (F2) Successful Target
UniProt ID THRB_HUMAN
Gene Name F2
Synonyms
Prothrombin; Coagulation factor II
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Representative Drug(s) MELAGATRAN Drug Info Ki = 1.2 nM [1]
Co-Target Name Plasma kallikrein (KLKB1) Successful Target
UniProt ID KLKB1_HUMAN
Gene Name KLKB1
Synonyms
Plasma prekallikrein; Plasma kallikrein light chain; Plasma kallikrein heavy chain; PKK; Kininogenin; KLK3; Fletcher factor
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Representative Drug(s) bis-triazole derivative 10 Drug Info Ki = 2.4 nM [2]
Co-Target Name Coagulation factor Xa (F10) Successful Target
UniProt ID FA10_HUMAN
Gene Name F10
Synonyms
Fxa; Factor Xa; F10; Activated coagulation factor X
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Representative Drug(s) bis-triazole derivative 10 Drug Info Ki = 206 nM [2]
Co-Target Name Tissue-type plasminogen activator (PLAT) Successful Target
UniProt ID TPA_HUMAN
Gene Name PLAT
Synonyms
TPA; T-plasminogen activator; T-PA; Reteplase; Alteplase
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Representative Drug(s) MELAGATRAN Drug Info Ki = 900 nM [3]
Co-Target Name Trypsin (TRY) Co-Target
UniProt ID TRY1_HUMAN; TRY2_HUMAN; TRY3_HUMAN
Gene Name PRSS1; PRSS2; PRSS3
Representative Drug(s) MELAGATRAN Drug Info Ki = 4.3 nM [4]
References  Top
REF 1 Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1017-22.
REF 2 A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem. 2012 Feb 9;55(3):1171-80.
REF 3 Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. J Med Chem. 2020 Feb 27;63(4):1445-1472.
REF 4 Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4779-84.

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