Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T88338 Target Info
Target Name Bacterial 23S ribosomal RNA (Bact 23S rRNA)
Synonyms
RrnL; Plastid 23S rRNA
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Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Lopinavir Drug Info Ki = 0.0013 nM Click to Show More [1]
2 Lopinavir Drug Info Ki = 0.005 nM [2]
3 Lopinavir Drug Info Ki = 0.026 nM [3]
4 Lopinavir Drug Info Ki = 0.029 nM [3]
Co-Target Name Monoamine oxidase type A (MAO-A) Successful Target
UniProt ID AOFA_HUMAN
Gene Name MAOA
Synonyms
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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Representative Drug(s) Linezolid Drug Info IC50 = 3.8 ug.mL-1 [4]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) Lopinavir Drug Info Ki = 410 nM [5]
References  Top
REF 1 Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4;11(11):1351-3.
REF 2 Rational approaches to improving selectivity in drug design. J Med Chem. 2012 Feb 23;55(4):1424-44.
REF 3 Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance. J Med Chem. 2008 Aug 14;51(15):4839-43.
REF 4 New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem. 2014 Jun 12;57(11):4487-97.
REF 5 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.

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