Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T88318 Target Info
Target Name Protein kinase C (PRKC)
Target Type Clinical trial Target
Gene Name NO-GeName
Biochemical Class Kinase
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name BDNF/NT-3 growth factors receptor (TrkB) Successful Target
UniProt ID NTRK2_HUMAN
Gene Name NTRK2
Synonyms
Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.0636 nM [1]
Co-Target Name Proto-oncogene c-Ros (ROS1) Successful Target
UniProt ID ROS1_HUMAN
Gene Name ROS1
Synonyms
c-Ros receptor tyrosine kinase; Receptor tyrosine kinase c-ros oncogene 1; ROS; Proto-oncogene tyrosine-protein kinase ROS; Proto-oncogene c-Ros-1; MCF3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.07 nM [2]
Co-Target Name Janus kinase 3 (JAK-3) Successful Target
UniProt ID JAK3_HUMAN
Gene Name JAK3
Synonyms
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.1 nM [3]
Co-Target Name Platelet-derived growth factor receptor alpha (PDGFRA) Successful Target
UniProt ID PGFRA_HUMAN
Gene Name PDGFRA
Synonyms
RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGFR2; PDGFR-alpha; PDGFR-2; PDGF-R-alpha; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 0.1 nM [4]
Co-Target Name Tyrosine-protein kinase SYK (SYK) Successful Target
UniProt ID KSYK_HUMAN
Gene Name SYK
Synonyms
p72-Syk; Spleen tyrosine kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 0.1 nM [4]
Co-Target Name Fms-like tyrosine kinase 3 (FLT-3) Successful Target
UniProt ID FLT3_HUMAN
Gene Name FLT3
Synonyms
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.18 nM [5]
Co-Target Name Janus kinase 2 (JAK-2) Successful Target
UniProt ID JAK2_HUMAN
Gene Name JAK2
Synonyms
Tyrosine-protein kinase JAK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.189 nM [1]
Co-Target Name NT-3 growth factor receptor (TrkC) Successful Target
UniProt ID NTRK3_HUMAN
Gene Name NTRK3
Synonyms
TrkC tyrosine kinase; Trk-C; TRKC; Neurotrophic tyrosine kinase receptor type 3; NT3 growth factor receptor; GP145TrkC; GP145-TrkC
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.22 nM [1]
Co-Target Name Epidermal growth factor receptor (EGFR) Successful Target
UniProt ID EGFR_HUMAN
Gene Name EGFR
Synonyms
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.29 nM [6]
Co-Target Name Proto-oncogene c-Ret (RET) Successful Target
UniProt ID RET_HUMAN
Gene Name RET
Synonyms
RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; Cadherin family member 12; CDHR16; CDHF12; C-ret
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.46 nM [4]
Co-Target Name Tropomyosin-related kinase A (TrkA) Successful Target
UniProt ID NTRK1_HUMAN
Gene Name NTRK1
Synonyms
gp140trk; Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; Neurotrophic tyrosine kinase receptor type 1; NGF-trk receptor type A; MTC; High affinity nerve growth factor receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.5 nM [7]
Co-Target Name Platelet-derived growth factor receptor beta (PDGFRB) Successful Target
UniProt ID PGFRB_HUMAN
Gene Name PDGFRB
Synonyms
Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.6 nM [7]
Co-Target Name Janus kinase 1 (JAK-1) Successful Target
UniProt ID JAK1_HUMAN
Gene Name JAK1
Synonyms
Tyrosine-protein kinase JAK1; JAK1B; JAK1A
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.627 nM [1]
Co-Target Name Rho-associated protein kinase 1 (ROCK1) Successful Target
UniProt ID ROCK1_HUMAN
Gene Name ROCK1
Synonyms
Rok; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated kinase 1; Rho kinase; ROCK1; ROCK; P160ROCK; P160(rock); P160 ROCK-1; Let-502 kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.64 nM [3]
Co-Target Name ALK tyrosine kinase receptor (ALK) Successful Target
UniProt ID ALK_HUMAN
Gene Name ALK
Synonyms
CD246; Anaplastic lymphoma kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.67 nM [8]
Co-Target Name Proto-oncogene c-Src (SRC) Successful Target
UniProt ID SRC_HUMAN
Gene Name SRC
Synonyms
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.83 nM [9]
Co-Target Name Tyrosine-protein kinase Kit (KIT) Successful Target
UniProt ID KIT_HUMAN
Gene Name KIT
Synonyms
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 ~ 1 nM [10]
Co-Target Name LCK tyrosine protein kinase (LCK) Successful Target
UniProt ID LCK_HUMAN
Gene Name LCK
Synonyms
p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.01 nM [3]
Co-Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target
UniProt ID VGFR2_HUMAN
Gene Name KDR
Synonyms
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.2 nM [11]
Co-Target Name Fibroblast growth factor receptor 2 (FGFR2) Successful Target
UniProt ID FGFR2_HUMAN
Gene Name FGFR2
Synonyms
Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.77 nM [12]
Co-Target Name Fyn tyrosine protein kinase (FYN) Successful Target
UniProt ID FYN_HUMAN
Gene Name FYN
Synonyms
Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Fyn p59-Fyn; Fyn Protooncogene Syn
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2 nM [13]
Co-Target Name Platelet-derived growth factor receptor (PDGFR) Successful Target
UniProt ID PGFRA_HUMAN; PGFRB_HUMAN
Gene Name NO-GeName
Synonyms
Platelet-derived growth factor receptor tyrosine kinase; PDGFR kinase; PDGF-R
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2 nM [14]
Co-Target Name Glycogen synthase kinase-3 alpha (GSK-3A) Successful Target
UniProt ID GSK3A_HUMAN
Gene Name GSK3A
Synonyms
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.4 nM [1]
Co-Target Name Tyrosine-protein kinase UFO (AXL) Successful Target
UniProt ID UFO_HUMAN
Gene Name AXL
Synonyms
UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3 nM [7]
Co-Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target
UniProt ID FGFR1_HUMAN
Gene Name FGFR1
Synonyms
c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.89 nM [1]
Co-Target Name Serine/threonine-protein kinase B-raf (BRAF) Successful Target
UniProt ID BRAF_HUMAN
Gene Name BRAF
Synonyms
V-Raf murine sarcoma viral oncogene homolog B1; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.5 nM [12]
Co-Target Name Insulin receptor (INSR) Successful Target
UniProt ID INSR_HUMAN
Gene Name INSR
Synonyms
IR; CD220 antigen; CD220
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 8.5 nM [4]
Co-Target Name Tyrosine-protein kinase BTK (ATK) Successful Target
UniProt ID BTK_HUMAN
Gene Name BTK
Synonyms
Bruton's tyrosine kinase; Bruton tyrosine kinase; BPK; B-cell progenitor kinase; B cell progenitor kinase; Agammaglobulinemia tyrosine kinase; Agammaglobulinaemia tyrosine kinase; AGMX1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 13.38 nM [3]
Co-Target Name Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target
UniProt ID ERBB4_HUMAN
Gene Name ERBB4
Synonyms
Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 28.3 nM [7]
Co-Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target
UniProt ID ABL1_HUMAN
Gene Name ABL1
Synonyms
p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 30 nM [15]
Co-Target Name Erbb2 tyrosine kinase receptor (HER2) Successful Target
UniProt ID ERBB2_HUMAN
Gene Name ERBB2
Synonyms
p185erbB2; Tyrosine kinase-type cell surface receptor HER2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; NGL; NEU; Metastatic lymph node gene 19 protein; MLN19; MLN 19; HER2; CD340
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 34 nM [16]
Co-Target Name Insulin-like growth factor I receptor (IGF1R) Successful Target
UniProt ID IGF1R_HUMAN
Gene Name IGF1R
Synonyms
Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 35.03 nM [17]
Co-Target Name Proto-oncogene c-Met (MET) Successful Target
UniProt ID MET_HUMAN
Gene Name MET
Synonyms
Tyrosine-protein kinase Met; Scatter factor receptor; SF receptor; Met proto-oncogene tyrosine kinase; Hepatocyte growth factor receptor; HGF/SF receptor; HGF-SF receptor; HGF receptor; C-met; C-Met receptor tyrosine kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 69.2 nM [7]
Co-Target Name Fusion protein Bcr-Abl (Bcr-Abl) Successful Target
UniProt ID BCR_HUMAN-ABL1_HUMAN
Gene Name BCR-ABL1
Synonyms
BCR-ABL fusion protein; BCR-ABL
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 121.8 nM [18]
Co-Target Name MAP kinase p38 (MAPK12) Successful Target
UniProt ID MK12_HUMAN
Gene Name MAPK12
Synonyms
Stress-activated protein kinase 3; SAPK3; Mitogen-activated proteinkinase p38 gamma; Mitogen-activated proteinkinase 12; MAPK12; Extracellular signal-regulated kinase 6; ERK6; ERK5; ERK-6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 275 nM [1]
Co-Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target
UniProt ID CDK2_HUMAN
Gene Name CDK2
Synonyms
Sin3 associated polypeptide; SIN3-associated protein; P33 protein kinase; Cell division protein kinase 2; CDKN2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.1 nM [19]
Co-Target Name Checkpoint kinase-1 (CHK1) Clinical trial Target
UniProt ID CHK1_HUMAN
Gene Name CHEK1
Synonyms
Serine/threonine-protein kinase Chk1; Chk1; Cell cycle checkpoint kinase; CHK1 checkpoint homolog
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 0.1 nM [4]
Co-Target Name TYK2 tyrosine kinase (TYK2) Successful Target
UniProt ID TYK2_HUMAN
Gene Name TYK2
Synonyms
Non-receptor tyrosine-protein kinase TYK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.205 nM [1]
Co-Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target
UniProt ID CDK1_HUMAN
Gene Name CDK1
Synonyms
P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.4 nM [20]
Co-Target Name Microtubule affinity regulating kinase 3 (MARK3) Clinical trial Target
UniProt ID MARK3_HUMAN
Gene Name MARK3
Synonyms
cTAK1; Serine/threonine-protein kinase p78; Ser/Thr protein kinase PAR-1; Protein kinase STK10); Protein kinase STK10; Par-1a; MAP/microtubule affinity-regulating kinase 3; EMK2; EMK-2; ELKL motif kinase 2; Cdc25C-associated protein kinase 1; C-TAK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.438 nM [1]
Co-Target Name Tyrosine-protein kinase Lyn (JTK8) Clinical trial Target
UniProt ID LYN_HUMAN
Gene Name LYN
Synonyms
p56Lyn; p53Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Lck/Yes-related novel protein tyrosine kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.473 nM [3]
Co-Target Name Maternal embryonic leucine zipper kinase (MELK) Clinical trial Target
UniProt ID MELK_HUMAN
Gene Name MELK
Synonyms
Protein kinase PK38; Protein kinase Eg3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.542 nM [1]
Co-Target Name Ribosomal protein S6 kinase beta-1 (S6K1) Clinical trial Target
UniProt ID KS6B1_HUMAN
Gene Name RPS6KB1
Synonyms
p70-S6K 1; p70 ribosomal S6 kinase alpha; p70 S6KA; p70 S6K-alpha; p70 S6 kinase alpha; Serine/threonine-protein kinase 14A; STK14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; P70-S6K; 70 kDa ribosomal protein S6 kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.553 nM [1]
Co-Target Name Aurora kinase A (AURKA) Clinical trial Target
UniProt ID AURKA_HUMAN
Gene Name AURKA
Synonyms
hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.6 nM [9]
Co-Target Name RAC-gamma serine/threonine-protein kinase (AKT3) Clinical trial Target
UniProt ID AKT3_HUMAN
Gene Name AKT3
Synonyms
STK-2; RAC-PK-gamma; Protein kinase B gamma; Protein kinase Akt-3; PKBG; PKB gamma
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.64 nM [21]
Co-Target Name Apoptosis signal-regulating kinase 1 (MAP3K5) Clinical trial Target
UniProt ID M3K5_HUMAN
Gene Name MAP3K5
Synonyms
Mitogen-activated protein kinase kinase kinase 5; MEKK5; MEKK 5; MEK kinase 5; MAPKKK5; MAPK/ERK kinase kinase 5; ASK1; ASK-1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.69 nM [22]
Co-Target Name Glucokinase (GCK) Clinical trial Target
UniProt ID HXK4_HUMAN
Gene Name GCK
Synonyms
Hexokinase type IV; Hexokinase D; HK4; HK IV
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.81 nM [1]
Co-Target Name Vascular endothelial growth factor receptor 3 (FLT-4) Clinical trial Target
UniProt ID VGFR3_HUMAN
Gene Name FLT4
Synonyms
VEGFR3; VEGFR-3; VEGF-3 receptor; Tyrosine-protein kinase receptor FLT4; Fms-like tyrosine kinase 4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.9 nM [7]
Co-Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB) Clinical trial Target
UniProt ID IKKB_HUMAN
Gene Name IKBKB
Synonyms
Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; IkBKB; IKKB; IKK2; IKK-beta; IKK-B; I-kappa-B-kinase beta; I-kappa-B kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.9 nM [23]
Co-Target Name Polo-like kinase 1 (PLK1) Clinical trial Target
UniProt ID PLK1_HUMAN
Gene Name PLK1
Synonyms
Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; Serine-threonine protein kinase 13; STPK13; Plk1; PLK-1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.92 ug.mL-1 [24]
Co-Target Name Rho-associated protein kinase 2 (ROCK2) Successful Target
UniProt ID ROCK2_HUMAN
Gene Name ROCK2
Synonyms
p164 ROCK-2; Rho-associated, coiled-coil-containing protein kinase II; Rho-associated, coiled-coil-containing protein kinase 2; Rho kinase 2; ROCK-II; KIAA0619
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.933 nM [1]
Co-Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target
UniProt ID MK01_HUMAN
Gene Name MAPK1
Synonyms
PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 1 nM [25]
Co-Target Name Aurora kinase B (AURKB) Clinical trial Target
UniProt ID AURKB_HUMAN
Gene Name AURKB
Synonyms
Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; STK5; STK12; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK2; ARK-2; AIRK2; AIM1; AIM-1; AIK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1 nM [26]
Co-Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target
UniProt ID LRRK2_HUMAN
Gene Name LRRK2
Synonyms
PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1 nM [27]
Co-Target Name Macrophage colony-stimulating factor 1 receptor (CSF1R) Clinical trial Target
UniProt ID CSF1R_HUMAN
Gene Name CSF1R
Synonyms
Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1R; CSF-1-R; CSF-1 receptor; CD115
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.14 nM [12]
Co-Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target
UniProt ID AKT1_HUMAN
Gene Name AKT1
Synonyms
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.5 nM [20]
Co-Target Name Mixed lineage kinase 1 (MAP3K9) Clinical trial Target
UniProt ID M3K9_HUMAN
Gene Name MAP3K9
Synonyms
PRKE1; Mitogen-activated protein kinase kinase kinase 9; MLK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.52 nM [1]
Co-Target Name PAK-4 protein kinase (PAK4) Clinical trial Target
UniProt ID PAK4_HUMAN
Gene Name PAK4
Synonyms
p21-activated kinase 4; Serine/threonine-protein kinase PAK 4; PAK-4; KIAA1142
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.9 nM [28]
Co-Target Name CaM-kinase II (CAMK2) Clinical trial Target
UniProt ID KCC2A_HUMAN; KCC2B_HUMAN; KCC2D_HUMAN; KCC2G_HUMAN
Gene Name CAMK2A; CAMK2B; CAMK2D; CAMK2G
Synonyms
Calcium/calmodulin-dependent protein kinase type II; CaMK-II; CaM kinase II; CAMK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2 nM [29]
Co-Target Name Yes tyrosine kinase (YES) Clinical trial Target
UniProt ID YES_HUMAN
Gene Name YES1
Synonyms
p61-Yes; Yes p59-Fyn; Yes Protooncogene Syn; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.35 nM [30]
Co-Target Name Aurora kinase C (AURKC) Clinical trial Target
UniProt ID AURKC_HUMAN
Gene Name AURKC
Synonyms
Serine/threonine-protein kinase aurora-C; STK13; Aurora/Ipl1/Eg2 protein 2; Aurora/Ipl1-related kinase 3; Aurora-related kinase 3; Aurora-C; Aurora 3; ARK3; ARK-3; AIRK3; AIK3; AIE2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.42 nM [1]
Co-Target Name ERK activator kinase 1 (MEK1) Clinical trial Target
UniProt ID MP2K1_HUMAN
Gene Name MAP2K1
Synonyms
PRKMK1; Mitogen-activated protein kinase kinase 1; MKK1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.5 nM Click to Show More [31]
2 Staurosporine Drug Info IC50 = 2.5 nM [31]
Co-Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target
UniProt ID GSK3B_HUMAN
Gene Name GSK3B
Synonyms
Serine/threonine-protein kinase GSK3B; GSK-3 beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.62 nM [12]
Co-Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target
UniProt ID PIM1_HUMAN
Gene Name PIM1
Synonyms
Pim-1 proto-oncogene, serine/threonine kinase; PIM
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.67 nM [3]
Co-Target Name Positive transcription elongation factor b (P-TEFb) Clinical trial Target
UniProt ID CDK9_HUMAN-CCNT1_HUMAN
Gene Name CDK9-CCNT1
Synonyms
P-TEFb
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.3 nM [21]
Co-Target Name Serine/threonine-protein kinase Chk2 (RAD53) Clinical trial Target
UniProt ID CHK2_HUMAN
Gene Name CHEK2
Synonyms
hCds1; Hucds1; Checkpoint kinase 2; Cds1 homolog; Cds1; CHK2 checkpoint homolog; CHK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.34 nM [9]
Co-Target Name Renal carcinoma antigen NY-REN-64 (IRAK-4) Clinical trial Target
UniProt ID IRAK4_HUMAN
Gene Name IRAK4
Synonyms
Interleukin-1 receptor-associated kinase 4; IRAK-4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.21 nM [1]
Co-Target Name Phosphoinositide dependent protein kinase-1 (PDPK1) Clinical trial Target
UniProt ID PDPK1_HUMAN
Gene Name PDPK1
Synonyms
PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.2 nM [32]
Co-Target Name Vascular endothelial growth factor receptor 1 (FLT-1) Clinical trial Target
UniProt ID VGFR1_HUMAN
Gene Name FLT1
Synonyms
Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.4 nM [7]
Co-Target Name Serine/threonine-protein kinase Sgk1 (SGK1) Clinical trial Target
UniProt ID SGK1_HUMAN
Gene Name SGK1
Synonyms
Serum/glucocorticoid-regulated kinase 1; SGK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.75 nM [1]
Co-Target Name Cyclin-dependent kinase 3 (CDK3) Clinical trial Target
UniProt ID CDK3_HUMAN
Gene Name CDK3
Synonyms
Cyclindependent kinase 3; Cell division protein kinase 3; CDKN3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.9 nM [21]
Co-Target Name Serine/threonine-protein kinase pim-2 (PIM2) Clinical trial Target
UniProt ID PIM2_HUMAN
Gene Name PIM2
Synonyms
Pim-2h; PIM2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 7 nM [33]
Co-Target Name Fibroblast growth factor receptor 3 (FGFR3) Clinical trial Target
UniProt ID FGFR3_HUMAN
Gene Name FGFR3
Synonyms
JTK4; FGFR-3; CD333
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 9.25 nM [3]
Co-Target Name T-cell-specific kinase (ITK) Clinical trial Target
UniProt ID ITK_HUMAN
Gene Name ITK
Synonyms
Tyrosine kinase ITK; Inducible T cell kinase; EMT
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10 nM [1]
Co-Target Name Myosin light kinase (MYLK) Clinical trial Target
UniProt ID MYLK_HUMAN
Gene Name MYLK
Synonyms
smMLCK; Telokin; Myosin light chain kinase, smooth muscle; MYLK1; MLCK210; MLCK1; MLCK; Kinase-related protein; KRP; Endothelial cell (EC) MLCK isoform; EC mlck; 210,000 molecular weight myosin light chain kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10 nM [34]
Co-Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target
UniProt ID MK14_HUMAN
Gene Name MAPK14
Synonyms
SAPK2A; P38 mitogen activatedprotein kinase; P38 Mitogen-activatedprotein kinase alpha; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MXI2; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10.5 nM [7]
Co-Target Name Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target
UniProt ID ERBB3_HUMAN
Gene Name ERBB3
Synonyms
Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB3; C-erbB-3 protein
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10.6 nM [7]
Co-Target Name Aldosterone synthase (CYP11B2) Clinical trial Target
UniProt ID C11B2_HUMAN
Gene Name CYP11B2
Synonyms
Steroid 18hydroxylase; Cytochrome P450C18; Cytochrome P450Aldo; Cytochrome P450 11B2, mitochondrial; CYPXIB2; CYP11B2; Aldosteronesynthesizing enzyme; ALDOS
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11 nM [35]
Co-Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target
UniProt ID FAK1_HUMAN
Gene Name PTK2
Synonyms
pp125FAK; p125FAK; Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Focal adhesion kinase-related nonkinase; FRNK; FAK1; FADK 1; FADK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11 nM [36]
Co-Target Name Tyrosine-protein kinase Mer (MERTK) Clinical trial Target
UniProt ID MERTK_HUMAN
Gene Name MERTK
Synonyms
Receptor tyrosine kinase MerTK; Proto-oncogene c-Mer
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11.6 nM [1]
Co-Target Name Protein kinase N3 (PKN3) Clinical trial Target
UniProt ID PKN3_HUMAN
Gene Name PKN3
Synonyms
Serine/threonine-protein kinase N3; Protein-kinase C-related kinase 3; Protein kinase PKN-beta; PKNBETA
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 13.2 nM [1]
Co-Target Name Ephrin type-A receptor 3 (EPHA3) Clinical trial Target
UniProt ID EPHA3_HUMAN
Gene Name EPHA3
Synonyms
hEK4; Tyrosineprotein kinase receptor ETK1; Tyrosineprotein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase TYRO4; TYRO4; Human embryo kinase; HEK; Ephrin typeA receptor 3; Ephlike tyrosine kinase 1; Eph-like tyrosine kinase 1; ETK1; ETK protein; EPHlike kinase 4; EPH-like kinase 4; EK4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 19.72 nM [3]
Co-Target Name MAP kinase signal-integrating kinase 2 (MKNK2) Clinical trial Target
UniProt ID MKNK2_HUMAN
Gene Name MKNK2
Synonyms
Mnk2; MAPK signal-integrating kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 20.3 nM [1]
Co-Target Name MAPK-activated protein kinase 2 (MAPKAPK2) Clinical trial Target
UniProt ID MAPK2_HUMAN
Gene Name MAPKAPK2
Synonyms
MK2; MK-2; MAPKactivated protein kinase 2; MAPKAPK-2; MAPKAP-K2; MAPKAP kinase 2; MAP kinaseactivated protein kinase 2; MAP kinase-activated protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 36.25 nM [17]
Co-Target Name ERK activator kinase 2 (MEK2) Clinical trial Target
UniProt ID MP2K2_HUMAN
Gene Name MAP2K2
Synonyms
PRKMK2; MKK2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; Dual specificity mitogenactivated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 37.4 nM [1]
Co-Target Name MAPK/ERK kinase kinase 2 (MAP3K2) Clinical trial Target
UniProt ID M3K2_HUMAN
Gene Name MAP3K2
Synonyms
Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 43.5 nM [1]
Co-Target Name Angiopoietin 1 receptor (TEK) Clinical trial Target
UniProt ID TIE2_HUMAN
Gene Name TEK
Synonyms
hTIE2; VMCM1; VMCM; Tyrosine-protein kinase receptor TIE-2; Tyrosine-protein kinase receptor TEK; Tyrosine kinase with Ig and EGF homology domains-2; Tunica interna endothelial cell kinase; TIE2; P140 TEK; Endothelial tyrosine kinase; Endothelial Cell-Specific Receptor TIE-2; CD202b antigen; CD202b
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 50.9 nM [3]
Co-Target Name MAPK signal-integrating kinase 1 (MKNK1) Clinical trial Target
UniProt ID MKNK1_HUMAN
Gene Name MKNK1
Synonyms
Mnk1; MAP kinase signal-integrating kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 52.7 nM [1]
Co-Target Name Ephrin type-A receptor 2 (EPHA2) Clinical trial Target
UniProt ID EPHA2_HUMAN
Gene Name EPHA2
Synonyms
Tyrosine-protein kinase receptor ECK; Epithelial cell kinase; EphA2receptor; ECK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 74.5 nM [1]
Co-Target Name Macrophage-stimulating protein receptor (RON) Clinical trial Target
UniProt ID RON_HUMAN
Gene Name MST1R
Synonyms
p185Ron; Proteintyrosine kinase 8; Macrophagestimulating protein receptor beta chain; Macrophagestimulating protein receptor; MST1R; MSP receptor; CDw136; CD136
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 102.7 nM [7]
Co-Target Name Fibroblast growth factor receptor 4 (FGFR4) Clinical trial Target
UniProt ID FGFR4_HUMAN
Gene Name FGFR4
Synonyms
TKF; JTK2; FGFR-4; CD334
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 107 nM [1]
Co-Target Name Ephrin type-B receptor 2 (EPHB2) Clinical trial Target
UniProt ID EPHB2_HUMAN
Gene Name EPHB2
Synonyms
hEK5; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5; TYRO5; Renal carcinoma antigen NY-REN-47; Receptor protein-tyrosine kinase HEK5; EphB2 receptor tyrosine kinase; EphB2; EPTH3; EPHT3; EPH-like kinase 5; EPH tyrosine kinase 3; ELK-related tyrosine kinase; EK5; Developmentally-regulated Eph-related tyrosine kinase; DRT
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 116 nM [1]
Co-Target Name Ephrin type-B receptor 4 (EPHB4) Clinical trial Target
UniProt ID EPHB4_HUMAN
Gene Name EPHB4
Synonyms
Tyrosine-protein kinase TYRO11; TYRO11; MYK1; Hepatoma transmembrane kinase; HTK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 126.4 nM [3]
Co-Target Name Proto-oncogene c-RAF (c-RAF) Clinical trial Target
UniProt ID RAF1_HUMAN
Gene Name RAF1
Synonyms
cRaf; Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 130 nM [37]
Co-Target Name Tyrosine-protein kinase BRK (PTK6) Clinical trial Target
UniProt ID PTK6_HUMAN
Gene Name PTK6
Synonyms
Protein-tyrosine kinase 6; Breast tumor kinase; BRK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 247 nM [7]
Co-Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target
UniProt ID MK08_HUMAN
Gene Name MAPK8
Synonyms
Stress-activated protein kinase 1c; SAPK1c; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 361 nM [1]
Co-Target Name Fibroblast growth factor receptor (FGFR) Clinical trial Target
UniProt ID FGFR1_HUMAN; FGFR2_HUMAN; FGFR3_HUMAN; FGFR4_HUMAN
Gene Name NO-GeName
Synonyms
FGF receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 420 nM [25]
Co-Target Name MAPK/ERK kinase kinase 1 (MAP3K1) Clinical trial Target
UniProt ID M3K1_HUMAN
Gene Name MAP3K1
Synonyms
Mitogenactivated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; MEKK1; MEKK 1; MEKK; MEK kinase 1; MAPKKK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 485 nM [1]
Co-Target Name Activin receptor-like kinase-1 (ACVRL1) Clinical trial Target
UniProt ID ACVL1_HUMAN
Gene Name ACVRL1
Synonyms
Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; ACVRLK1; ACVRL1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 850 nM [38]
Co-Target Name Stress-activated protein kinase (p38) Clinical trial Target
UniProt ID MK11_HUMAN; MK12_HUMAN; MK13_HUMAN; MK14_HUMAN
Gene Name NO-GeName
Synonyms
p38) Stress-activated protein kinase; P38 MAPK; P38 MAP kinase; Mitogen-activated protein kinase p38
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 1000 nM [25]
Co-Target Name PIM-3 protein kinase (PIM3) Patented-recorded Target
UniProt ID PIM3_HUMAN
Gene Name PIM3
Synonyms
Serine/threonine-protein kinase pim-3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.0885 nM [1]
Co-Target Name Ribosomal protein S6 kinase alpha-1 (RSK1) Patented-recorded Target
UniProt ID KS6A1_HUMAN
Gene Name RPS6KA1
Synonyms
p90S6K; p90RSK1; p90-RSK 1; S6K-alpha-1; Ribosomal S6 kinase 1; RSK-1; MAPKAPK1A; MAPKAPK-1a; MAPKAP kinase 1a; MAPK-activated protein kinase 1a; MAP kinase-activated protein kinase 1a; 90 kDa ribosomal protein S6 kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.09 nM [3]
Co-Target Name Ribosomal protein S6 kinase alpha-3 (RSK3) Patented-recorded Target
UniProt ID KS6A3_HUMAN
Gene Name RPS6KA3
Synonyms
pp90RSK2; p90RSK3; p90-RSK 3; S6K-alpha-3; Ribosomal S6 kinase 2; RSK2; RSK-2; MAPKAPK1B; MAPKAPK-1b; MAPKAP kinase 1b; MAPK-activated protein kinase 1b; MAP kinase-activated protein kinase 1b; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; 90 kDa ribosomal protein S6 kinase 3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.124 nM [1]
Co-Target Name Ribosomal protein S6 kinase alpha-6 (RSK6) Patented-recorded Target
UniProt ID KS6A6_HUMAN
Gene Name RPS6KA6
Synonyms
pp90RSK4; p90RSK6; p90-RSK 6; S6K-alpha-6; Ribosomal S6 kinase 4; RSK4; RSK-4; 90 kDa ribosomal protein S6 kinase 6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.159 nM [1]
Co-Target Name Pyruvate dehydrogenase kinase 1 (PDHK1) Patented-recorded Target
UniProt ID PDK1_HUMAN
Gene Name PDK1
Synonyms
Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; PDHK1; PDH kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.506 nM [1]
Co-Target Name MEK kinase kinase 4 (MAP4K4) Patented-recorded Target
UniProt ID M4K4_HUMAN
Gene Name MAP4K4
Synonyms
Nckinteracting kinase; Nck-interacting kinase; Mitogenactivated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; MEKKK 4; MAPK/ERK kinase kinase kinase 4; KIAA0687; HPK/GCKlike kinase HGK; HPK/GCK-like kinase HGK; HGK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.57 nM [1]
Co-Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) Patented-recorded Target
UniProt ID DYR1B_HUMAN
Gene Name DYRK1B
Synonyms
Minibrain-related kinase; MIRK; Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.967 nM [1]
Co-Target Name B lymphocyte kinase (BLK) Patented-recorded Target
UniProt ID BLK_HUMAN
Gene Name BLK
Synonyms
p55-Blk; Tyrosine-protein kinase Blk
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.07 nM [1]
Co-Target Name Discoidin domain-containing receptor 2 (DDR2) Patented-recorded Target
UniProt ID DDR2_HUMAN
Gene Name DDR2
Synonyms
Tyrosine-protein kinase TYRO10; Receptor protein-tyrosine kinase TKT; Neurotrophic tyrosine kinase, receptor-related 3; Discoidin domain-containing receptor tyrosine kinase 2; Discoidin domain receptor 2; DDR2; CD167 antigen-like family member B
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.19 nM [1]
Co-Target Name Tyrosine-protein kinase ZAP-70 (ZAP-70) Patented-recorded Target
UniProt ID ZAP70_HUMAN
Gene Name ZAP70
Synonyms
Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.3 nM [36]
Co-Target Name Ribosomal protein S6 kinase alpha-5 (RSK5) Patented-recorded Target
UniProt ID KS6A5_HUMAN
Gene Name RPS6KA5
Synonyms
S6K-alpha-5; RSKL; RSK-like protein kinase; Nuclear mitogen- and stress-activated protein kinase 1; MSK1; 90 kDa ribosomal protein S6 kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.4 nM [32]
Co-Target Name Hematopoietic cell kinase (HCK) Patented-recorded Target
UniProt ID HCK_HUMAN
Gene Name HCK
Synonyms
p61Hck; p59Hck; p59-HCK/p60-HCK; Tyrosine-protein kinase HCK; Hemopoietic cell kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.9 nM [1]
Co-Target Name NF-kappa-B-activating kinase (TBK1) Patented-recorded Target
UniProt ID TBK1_HUMAN
Gene Name TBK1
Synonyms
TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.18 nM [1]
Co-Target Name TYRO3 tyrosine kinase receptor (TYRO3) Patented-recorded Target
UniProt ID TYRO3_HUMAN
Gene Name TYRO3
Synonyms
Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase TIF; Tyrosine-protein kinase SKY; Tyrosine-protein kinase RSE; Tyrosine-protein kinase DTK; Tyrosine-protein kinase BYK; TIF; SKY; RSE; DTK; BYK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.75 nM [1]
Co-Target Name Epithelial discoidin domain receptor 1 (DDR1) Patented-recorded Target
UniProt ID DDR1_HUMAN
Gene Name DDR1
Synonyms
Tyrosine-protein kinase CAK; Tyrosine kinase DDR; TRKE; TRK E; RTK6; Protein-tyrosine kinase RTK-6; Protein-tyrosine kinase 3A; PTK3A; NTRK4; NEP; Mammary carcinoma kinase 10; MCK-10; HGK2; Epithelial discoidin domain-containing receptor 1; EDDR1; Discoidin receptor tyrosine kinase; Cell adhesion kinase; CD167a; CD167 antigen-like family member A
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.28 nM [1]
Co-Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) Patented-recorded Target
UniProt ID DYR1A_HUMAN
Gene Name DYRK1A
Synonyms
hMNB; Protein kinase minibrain homolog; MNBH; MNB; HP86; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; DYRK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.93 nM [1]
Co-Target Name CDC-like kinase 2 (CLK2) Patented-recorded Target
UniProt ID CLK2_HUMAN
Gene Name CLK2
Synonyms
Dual specificity protein kinase CLK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.52 nM [1]
Co-Target Name Tyrosine-protein kinase BMX (BMX) Patented-recorded Target
UniProt ID BMX_HUMAN
Gene Name BMX
Synonyms
NTK38; Epithelial and endothelial tyrosine kinase; ETK; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.16 nM [1]
Co-Target Name CDC-like kinase 1 (CLK1) Patented-recorded Target
UniProt ID CLK1_HUMAN
Gene Name CLK1
Synonyms
Dual specificity protein kinase CLK1; CLK; CDClike kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 14.2 nM [1]
Co-Target Name Tyrosine-protein kinase CSK (CSK) Patented-recorded Target
UniProt ID CSK_HUMAN
Gene Name CSK
Synonyms
Protein-tyrosine kinase CYL; C-Src kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 14.3 nM [1]
Co-Target Name SPS1/STE20-related protein kinase YSK4 (YSK4) Patented-recorded Target
UniProt ID M3K19_HUMAN
Gene Name MAP3K19
Synonyms
Regulated in COPD, protein kinase; RCK; Mitogen-activated protein kinase kinase kinase 19
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 15.6 nM [1]
Co-Target Name SRSF protein kinase 1 (SRPK1) Patented-recorded Target
UniProt ID SRPK1_HUMAN
Gene Name SRPK1
Synonyms
Serine/arginine-rich protein-specific kinase 1; SR-protein-specific kinase 1; SFRS protein kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 24.5 nM [1]
Co-Target Name Calmodulin-dependent kinase II (CAMKK2) Patented-recorded Target
UniProt ID KKCC2_HUMAN
Gene Name CAMKK2
Synonyms
KIAA0787; Calcium/calmodulin-dependent protein kinase kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; CaMKK beta; CaMKK 2; CaM-kinase kinase beta; CaM-kinase kinase 2; CaM-KK beta; CaM-KK 2; CAMKKB
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 33.6 nM [1]
Co-Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) Patented-recorded Target
UniProt ID DYRK3_HUMAN
Gene Name DYRK3
Synonyms
Regulatory erythroid kinase; REDK; Dual specificity tyrosine-phosphorylation-regulated kinase 3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 34.8 nM [1]
Co-Target Name Activated CDC42 kinase 1 (ACK-1) Patented-recorded Target
UniProt ID ACK1_HUMAN
Gene Name TNK2
Synonyms
Tyrosine kinase non-receptor protein 2; ACK1; ACK-1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 34.8 nM [1]
Co-Target Name Tyrosine-protein kinase Tec (PSCTK4) Patented-recorded Target
UniProt ID TEC_HUMAN
Gene Name TEC
Synonyms
Tec protein tyrosine kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 43.1 nM [1]
Co-Target Name IL-1 receptor-associated kinase 1 (IRAK1) Patented-recorded Target
UniProt ID IRAK1_HUMAN
Gene Name IRAK1
Synonyms
Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 59.3 nM [1]
Co-Target Name G protein-coupled receptor kinase 5 (GRK5) Patented-recorded Target
UniProt ID GRK5_HUMAN
Gene Name GRK5
Synonyms
GPRK5; G protein-coupled receptor kinase GRK5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 73.3 nM [1]
Co-Target Name Tyrosine-protein kinase EIF2AK2 (p68) Patented-recorded Target
UniProt ID E2AK2_HUMAN
Gene Name EIF2AK2
Synonyms
p68 kinase; Proteinkinase RNA-activated; Interferon-inducible RNA-dependent protein kinase p68; Interferon-induced, double-stranded RNA-activated protein kinase p68
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 100 nM [39]
Co-Target Name Extracellular signal-regulated kinase 5 (ERK5) Patented-recorded Target
UniProt ID MK07_HUMAN
Gene Name MAPK7
Synonyms
PRKM7; Mitogen-activated protein kinase 7; MAPK 7; MAP kinase 7; ERK-5; Big MAP kinase 1; BMK1; BMK-1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 121.6 nM [3]
Co-Target Name Polo-like kinase 2 (PLK2) Patented-recorded Target
UniProt ID PLK2_HUMAN
Gene Name PLK2
Synonyms
hSNK; hPlk2; Serum-inducible kinase; Serine/threonine-protein kinase SNK; Serine/threonine-protein kinase PLK2; SNK; PLK-2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 197 nM [4]
Co-Target Name Endoplasmic reticulum to nucleus signaling 1 (ERN1) Patented-recorded Target
UniProt ID ERN1_HUMAN
Gene Name ERN1
Synonyms
Serine/threonine-protein kinase/endoribonuclease IRE1; Ire1-alpha; IRE1a; IRE1; Inositol-requiring protein 1; hIRE1p; Endoplasmic reticulum-to-nucleus signaling 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 204 nM [1]
Co-Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) Patented-recorded Target
UniProt ID DYRK2_HUMAN
Gene Name DYRK2
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 248 nM [1]
Co-Target Name Casein kinase II alpha prime (CSNK2A2) Patented-recorded Target
UniProt ID CSK22_HUMAN
Gene Name CSNK2A2
Synonyms
Casein kinase II subunit alpha'; CK2A2; CK II alpha'
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 844 nM [1]
Co-Target Name MAPK-activated protein kinase 5 (MAPKAPK5) Discontinued Target
UniProt ID MAPK5_HUMAN
Gene Name MAPKAPK5
Synonyms
p38regulated/activated protein kinase; p38-regulated/activated protein kinase; PRAK; MK5; MK-5; MAPKactivated protein kinase 5; MAPKAPK-5; MAPKAP-K5; MAPKAP kinase 5; MAP kinaseactivated protein kinase 5; MAP kinase-activated protein kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 295 nM [1]
Co-Target Name MEK kinase kinase 3 (MAP4K3) Literature-reported Target
UniProt ID M4K3_HUMAN
Gene Name MAP4K3
Synonyms
RAB8IPL1; Mitogen-activated protein kinase kinase kinase kinase 3; MEKKK 3; MAPK/ERK kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.0825 nM [1]
Co-Target Name Phosphorylase kinase testis gamma 2 (PHKG2) Literature-reported Target
UniProt ID PHKG2_HUMAN
Gene Name PHKG2
Synonyms
Phosphorylase kinase subunit gamma-2; Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; PSK-C3; PHK-gamma-T; PHK-gamma-LT
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 0.1 nM [4]
Co-Target Name HUMAN microtubule affinity regulating kinase 2 (MARK2) Literature-reported Target
UniProt ID MARK2_HUMAN
Gene Name MARK2
Synonyms
Par-1b; Par1b; PAR1 homolog b; PAR1 homolog; MAP/microtubule affinity-regulating kinase 2; EMK-1; ELKL motif kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.133 nM [1]
Co-Target Name Ribosomal protein S6 kinase alpha-2 (RSK2) Literature-reported Target
UniProt ID KS6A2_HUMAN
Gene Name RPS6KA2
Synonyms
pp90RSK3; p90RSK2; p90-RSK 2; S6K-alpha-2; Ribosomal S6 kinase 3; RSK3; RSK-3; MAPKAPK1C; MAPKAPK-1c; MAPKAP kinase 1c; MAPK-activated protein kinase 1c; MAP kinase-activated protein kinase 1c; 90 kDa ribosomal protein S6 kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.227 nM [1]
Co-Target Name PAK-1 protein kinase (PAK1) Literature-reported Target
UniProt ID PAK1_HUMAN
Gene Name PAK1
Synonyms
p65-PAK; p21-activated kinase 1; Serine/threonine-protein kinase PAK 1; PAK-1; Alpha-PAK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.3 nM [3]
Co-Target Name Proto-oncogene c-Fer (FER) Literature-reported Target
UniProt ID FER_HUMAN
Gene Name FER
Synonyms
p94-Fer; Tyrosine-protein kinase Fer; Tyrosine kinase 3; TYK3; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Feline encephalitis virus-related kinase FER
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.365 nM [1]
Co-Target Name Salt-inducible kinase 2 (SIK2) Clinical trial Target
UniProt ID SIK2_HUMAN
Gene Name SIK2
Synonyms
Serine/threonine-protein kinase SNF1-like kinase 2; Serine/threonine-protein kinase SIK2; SNF1LK2; SIK-2; Qin-induced kinase; QIK; KIAA0781
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.37 nM [1]
Co-Target Name TRAF2 and NCK interacting kinase (TNIK) Literature-reported Target
UniProt ID TNIK_HUMAN
Gene Name TNIK
Synonyms
TRAF2 and NCK-interacting protein kinase; KIAA0551
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.551 nM [1]
Co-Target Name Non-receptor tyrosine-protein kinase TNK1 (TNK1) Literature-reported Target
UniProt ID TNK1_HUMAN
Gene Name TNK1
Synonyms
CD38 negative kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.584 nM [1]
Co-Target Name NDR1 protein kinase (STK38) Literature-reported Target
UniProt ID STK38_HUMAN
Gene Name STK38
Synonyms
Serine/threonine-protein kinase 38; Nuclear Dbf2-related kinase 1; NDR1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.628 nM [1]
Co-Target Name BR serine/threonine kinase 1 (BRSK1) Literature-reported Target
UniProt ID BRSK1_HUMAN
Gene Name BRSK1
Synonyms
hSAD1; Synapses of Amphids Defective homolog 1; Serine/threonine-protein kinase SAD-B; Serine/threonine-protein kinase BRSK1; SADB; SAD1 homolog; SAD1; KIAA1811; Brain-specific serine/threonine-protein kinase 1; Brain-selective kinase 1; BR serine/threonine-protein kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.856 nM [1]
Co-Target Name HUMAN protein kinase cAMP-activated catalytic subunit alpha (PRKACA) Literature-reported Target
UniProt ID KAPCA_HUMAN
Gene Name PRKACA
Synonyms
PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.935 nM [1]
Co-Target Name PAK-2 protein kinase (PAK2) Literature-reported Target
UniProt ID PAK2_HUMAN
Gene Name PAK2
Synonyms
p21-activated kinase 2; Serine/threonine-protein kinase PAK 2; S6/H4 kinase; PAK65; PAK-2; Gamma-PAK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1 nM [4]
Co-Target Name Protein kinase N1 (PKN1) Literature-reported Target
UniProt ID PKN1_HUMAN
Gene Name PKN1
Synonyms
Serine/threonine-protein kinase N1; Serine-threonine protein kinase N; Protein-kinase C-related kinase 1; Protein kinase PKN-alpha; Protein kinase C-like PKN; Protein kinase C-like 1; Protease-activated kinase 1; PRKCL1; PRK1; PKN; PAK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1 nM [40]
Co-Target Name Tyrosine-protein kinase Fgr (FGR) Literature-reported Target
UniProt ID FGR_HUMAN
Gene Name FGR
Synonyms
p58c-Fgr; p58-Fgr; p55-Fgr; SRC2; Proto-oncogene c-Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.15 nM [1]
Co-Target Name TAO kinase 1 (TAOK1) Literature-reported Target
UniProt ID TAOK1_HUMAN
Gene Name TAOK1
Synonyms
hTAOK1; hKFC-B; Thousand and one amino acid protein kinase 1; TAOK1; Serine/threonine-protein kinase TAO1; Prostate-derived sterile 20-like kinase 2; Prostate-derived STE20-like kinase 2; PSK2; PSK-2; MARKK; MARK Kinase; MAP3K16; Kinase from chicken homolog B; KIAA1361
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.21 nM [1]
Co-Target Name Protein kinase G1 (PRKG1) Literature-reported Target
UniProt ID KGP1_HUMAN
Gene Name PRKG1
Synonyms
cGMP-dependent protein kinase I; cGMP-dependent protein kinase 1; cGKI; cGK1; cGK 1; PRKGR1B; PRKGR1A; PRKG1B
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.23 nM [1]
Co-Target Name SIK family kinase 3 (SIK3) Clinical trial Target
UniProt ID SIK3_HUMAN
Gene Name SIK3
Synonyms
Serine/threonine-protein kinase SIK3; Serine/threonine-protein kinase QSK; Salt-inducible kinase 3; SIK-3; KIAA0999
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.24 nM [1]
Co-Target Name Omphalocele kinase 1 (NUAK1) Literature-reported Target
UniProt ID NUAK1_HUMAN
Gene Name NUAK1
Synonyms
OMPHK1; NUAK family SNF1-like kinase 1; KIAA0537; ARK5; AMPK-related protein kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.31 nM [41]
Co-Target Name Salt-inducible kinase 1 (SIK1) Literature-reported Target
UniProt ID SIK1_HUMAN
Gene Name SIK1
Synonyms
Serine/threonine-protein kinase SNF1LK; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SIK1; SNF1LK; SIK-1; SIK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.34 nM [1]
Co-Target Name NDR2 protein kinase (STK38L) Literature-reported Target
UniProt ID ST38L_HUMAN
Gene Name STK38L
Synonyms
Serine/threonine-protein kinase 38-like; Nuclear Dbf2-related kinase 2; NDR2; KIAA0965
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.47 nM [1]
Co-Target Name Proto-oncogene c-Fes (FES) Literature-reported Target
UniProt ID FES_HUMAN
Gene Name FES
Synonyms
p93c-fes; Tyrosine-protein kinase Fes/Fps; Proto-oncogene c-Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; FPS
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.52 nM [1]
Co-Target Name MST-1 protein kinase (STK4) Literature-reported Target
UniProt ID STK4_HUMAN
Gene Name STK4
Synonyms
Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4 18kDa subunit; Serine/threonine-protein kinase 4; STE20-like kinase MST1; Mammalian STE20-like protein kinase 1; MST1/N; MST1/C; MST1; MST-1; KRS2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.58 nM [1]
Co-Target Name NUAK family SNF1-like kinase 2 (NUAK2) Literature-reported Target
UniProt ID NUAK2_HUMAN
Gene Name NUAK2
Synonyms
SNF1/AMP kinase-related kinase; SNARK; Omphalocele kinase 2; OMPHK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.67 nM [1]
Co-Target Name Protein kinase N2 (PKN2) Literature-reported Target
UniProt ID PKN2_HUMAN
Gene Name PKN2
Synonyms
Serine/threonine-protein kinase N2; Protein-kinase C-related kinase 2; Protein kinase C-like 2; PRKCL2; PRK2; PKN gamma
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.97 nM [41]
Co-Target Name TAO kinase 3 (TAOK3) Literature-reported Target
UniProt ID TAOK3_HUMAN
Gene Name TAOK3
Synonyms
hKFC-A; Thousand and one amino acid protein 3; Serine/threonine-protein kinase TAO3; MAP3K18; Kinase from chicken homolog A; KDS; Jun kinase-inhibitory kinase; JNK/SAPK-inhibitory kinase; JIK; Dendritic cell-derived protein kinase; DPK; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.11 nM [1]
Co-Target Name BR serine/threonine kinase 2 (BRSK2) Literature-reported Target
UniProt ID BRSK2_HUMAN
Gene Name BRSK2
Synonyms
Serine/threonine-protein kinase SAD-A; Serine/threonine-protein kinase BRSK2; Serine/threonine-protein kinase 29; STK29; SADA; PEN11B; HUSSY-12; C11orf7; Brain-specific serine/threonine-protein kinase 2; Brain-selective kinase 2; BR serine/threonine-protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.33 nM [1]
Co-Target Name LIM domain kinase-1 (LIMK-1) Literature-reported Target
UniProt ID LIMK1_HUMAN
Gene Name LIMK1
Synonyms
LIMK-1; LIMK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.44 nM [1]
Co-Target Name Mixed lineage kinase 2 (MAP3K10) Literature-reported Target
UniProt ID M3K10_HUMAN
Gene Name MAP3K10
Synonyms
Protein kinase MST; Mitogen-activated protein kinase kinase kinase 10; MST; MLK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.69 nM [1]
Co-Target Name Death-associated protein kinase 3 (DAPK3) Literature-reported Target
UniProt ID DAPK3_HUMAN
Gene Name DAPK3
Synonyms
Zipper-interacting protein kinase; ZIPK; ZIP-kinase; MYPT1 kinase; DAP-like kinase; DAP kinase 3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.45 nM [1]
Co-Target Name Leukocyte receptor tyrosine kinase (LTK) Literature-reported Target
UniProt ID LTK_HUMAN
Gene Name LTK
Synonyms
TYK1; Protein tyrosine kinase 1; Leukocyte tyrosine kinase receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.6 nM [7]
Co-Target Name Large tumor suppressor homolog 2 (LATS2) Literature-reported Target
UniProt ID LATS2_HUMAN
Gene Name LATS2
Synonyms
Warts-like kinase; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; KPM
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.76 nM [1]
Co-Target Name Muscle-specific kinase receptor (MUSK) Literature-reported Target
UniProt ID MUSK_HUMAN
Gene Name MUSK
Synonyms
Muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal receptor tyrosine-protein kinase; MuSK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.8 nM [7]
Co-Target Name Mixed lineage kinase 3 (MAP3K11) Literature-reported Target
UniProt ID M3K11_HUMAN
Gene Name MAP3K11
Synonyms
Src-homology 3 domain-containing proline-rich kinase; SPRK; SH3 domain-containing proline-rich kinase; Protein-tyrosine kinase PTK1; PTK1; Mixed-lineage protein kinase 3; Mitogen-activated protein kinase kinase kinase 11; MLK3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4 nM [1]
Co-Target Name Unc-51 like kinase 3 (ULK3) Literature-reported Target
UniProt ID ULK3_HUMAN
Gene Name ULK3
Synonyms
Unc-51-like kinase 3; Serine/threonine-protein kinase ULK3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.2 nM [1]
Co-Target Name Testis-specific serine kinase 2 (TSSK2) Literature-reported Target
UniProt ID TSSK2_HUMAN
Gene Name TSSK2
Synonyms
Testis-specific serine/threonine-protein kinase 2; TSSK-2; TSK2; TSK-2; Serine/threonine-protein kinase 22B; STK22B; SPOGA2; DiGeorge syndrome protein G; DGSG; DGS-G
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.32 nM [1]
Co-Target Name CDC42 binding protein kinase alpha (DMPK-like alpha) Literature-reported Target
UniProt ID MRCKA_HUMAN
Gene Name CDC42BPA
Synonyms
Serine/threonine-protein kinase MRCK alpha; Myotonic dystrophy protein kinase-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; KIAA0451; CDC42-binding protein kinase alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.35 nM [1]
Co-Target Name Protein kinase G2 (PRKG2) Literature-reported Target
UniProt ID KGP2_HUMAN
Gene Name PRKG2
Synonyms
cGMP-dependent protein kinase II; cGMP-dependent protein kinase 2; cGKII; cGK2; cGK 2; PRKGR2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.77 nM [1]
Co-Target Name RAC-beta serine/threonine-protein kinase (AKT2) Literature-reported Target
UniProt ID AKT2_HUMAN
Gene Name AKT2
Synonyms
RAC-PK-beta; Protein kinase B beta; Protein kinase Akt-2; PKB beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.5 nM [42]
Co-Target Name Serine/threonine-protein kinase ULK1 (ULK1) Literature-reported Target
UniProt ID ULK1_HUMAN
Gene Name ULK1
Synonyms
hATG1; Unc-51-like kinase 1; KIAA0722; Autophagy-related protein 1 homolog; ATG1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 8.95 nM [1]
Co-Target Name Polo-like kinase 4 (PLK4) Literature-reported Target
UniProt ID PLK4_HUMAN
Gene Name PLK4
Synonyms
Serine/threonine-protein kinase Sak; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase 18; STK18; SAK; PLK-4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 9.49 nM [1]
Co-Target Name Focal adhesion kinase 2 (PTK2B) Literature-reported Target
UniProt ID FAK2_HUMAN
Gene Name PTK2B
Synonyms
Related adhesion focal tyrosine kinase; RAFTK; Protein-tyrosine kinase 2-beta; Proline-rich tyrosine kinase 2; PYK2; FAK2; FADK 2; Cell adhesion kinase beta; Calcium-regulated non-receptor proline-rich tyrosine kinase; Calcium-dependent tyrosine kinase; CAKB; CAK-beta; CADTK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10.6 nM [1]
Co-Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target
UniProt ID M3K3_HUMAN
Gene Name MAP3K3
Synonyms
Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 10.9 nM [1]
Co-Target Name Ephrin type-A receptor 6 (EPHA6) Literature-reported Target
UniProt ID EPHA6_HUMAN
Gene Name EPHA6
Synonyms
HEK12; EPH-like kinase 12; EPH homology kinase 2; EK12; EHK2; EHK-2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11.8 nM [1]
Co-Target Name Ephrin type-A receptor 4 (EPHA4) Literature-reported Target
UniProt ID EPHA4_HUMAN
Gene Name EPHA4
Synonyms
hEK8; Tyrosineprotein kinase receptor SEK; Tyrosineprotein kinase TYRO1; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1; TYRO1; SEK; Ephrin typeA receptor 4; EPHlike kinase 8; EPH-like kinase 8; EK8
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 12.5 nM [1]
Co-Target Name Myosin light chain kinase 2 (MYLK2) Literature-reported Target
UniProt ID MYLK2_HUMAN
Gene Name MYLK2
Synonyms
MYLK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 13.9 nM [1]
Co-Target Name Ste-20-related kinase (STK39) Literature-reported Target
UniProt ID STK39_HUMAN
Gene Name STK39
Synonyms
Serine/threonine-protein kinase 39; STE20/SPS1-related proline-alanine-rich protein kinase; SPAK; DCHT
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 14.4 nM [1]
Co-Target Name STE20-related serine/threonine-protein kinase (SLK) Literature-reported Target
UniProt ID SLK_HUMAN
Gene Name SLK
Synonyms
hSLK; STE20-related kinase; STE20-like kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 14.6 nM [1]
Co-Target Name Tyrosine-protein kinase ABL2 (ABL2) Literature-reported Target
UniProt ID ABL2_HUMAN
Gene Name ABL2
Synonyms
Tyrosine-protein kinase ARG; Abelson-related gene protein; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; ARG; ABLL
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 15.8 nM [1]
Co-Target Name PAS domain-containing serine/threonine-protein kinase (PASK) Literature-reported Target
UniProt ID PASK_HUMAN
Gene Name PASK
Synonyms
hPASK; PASKIN; PAS-kinase; KIAA0135
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 15.8 nM [1]
Co-Target Name Serine/threonine-protein kinase Nek8 (NEK8) Literature-reported Target
UniProt ID NEK8_HUMAN
Gene Name NEK8
Synonyms
Nima-related protein kinase 12a; NimA-related protein kinase 8; Never in mitosis A-related kinase 8; NEK12A; JCK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 17.5 nM [1]
Co-Target Name NIMA-related kinase 1 (NEK1) Literature-reported Target
UniProt ID NEK1_HUMAN
Gene Name NEK1
Synonyms
Serine/threonine-protein kinase Nek1; Renal carcinoma antigen NY-REN-55; NimA-related protein kinase 1; Never in mitosis A-related kinase 1; KIAA1901
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 18.4 nM [1]
Co-Target Name Ephrin type-A receptor 5 (EPHA5) Literature-reported Target
UniProt ID EPHA5_HUMAN
Gene Name EPHA5
Synonyms
hEK7; EPH-like kinase 7; EPH homology kinase 1; EK7; EHK1; EHK-1; Brain-specific kinase; BSK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 21.5 nM [1]
Co-Target Name Tyrosine-protein kinase TXK (TXK) Literature-reported Target
UniProt ID TXK_HUMAN
Gene Name TXK
Synonyms
Resting lymphocyte kinase; RLK; Protein-tyrosine kinase 4; PTK4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 21.6 nM [1]
Co-Target Name Cytoplasmic DRAK1 (STK17A) Literature-reported Target
UniProt ID ST17A_HUMAN
Gene Name STK17A
Synonyms
Serine/threonine-protein kinase 17A; STK17A; DAP kinase-related apoptosis-inducing protein kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 30.4 nM [1]
Co-Target Name CDC-like kinase 4 (CLK4) Literature-reported Target
UniProt ID CLK4_HUMAN
Gene Name CLK4
Synonyms
Dual specificity protein kinase CLK4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 33.6 nM [1]
Co-Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target
UniProt ID M3K7_HUMAN
Gene Name MAP3K7
Synonyms
Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 35 nM [4]
Co-Target Name Serine/threonine-protein kinase 33 (STK33) Literature-reported Target
UniProt ID STK33_HUMAN
Gene Name STK33
Synonyms
STK33
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 36.3 nM [1]
Co-Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target
UniProt ID IKKA_HUMAN
Gene Name CHUK
Synonyms
Transcription factor 16; TCF16; TCF-16; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IkappaB kinase A; IkBKA; IKK1; IKK-alpha; IKK-A; I-kappa-B kinase alpha; I-kappa-B kinase 1; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 39 nM [43]
Co-Target Name ERK activator kinase 5 (MAP2K5) Literature-reported Target
UniProt ID MP2K5_HUMAN
Gene Name MAP2K5
Synonyms
PRKMK5; Mitogen-activatedprotein kinase kinase 5; MKK5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 40.4 nM [1]
Co-Target Name CaM-kinase IV kinase (CAMKK1) Literature-reported Target
UniProt ID KKCC1_HUMAN
Gene Name CAMKK1
Synonyms
Calcium/calmodulin-dependent protein kinase kinase alpha; Calcium/calmodulin-dependent protein kinase kinase 1; CaMKK alpha; CaMKK 1; CaM-kinase kinase alpha; CaM-kinase kinase 1; CaM-KK alpha; CaM-KK 1; CAMKKA
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 42 nM [1]
Co-Target Name Yet another novel kinase 2 (STK32B) Literature-reported Target
UniProt ID ST32B_HUMAN
Gene Name STK32B
Synonyms
YANK2; Serine/threonine-protein kinase 32B
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 49.1 nM [1]
Co-Target Name Ephrin type-A receptor 1 (EPHA1) Literature-reported Target
UniProt ID EPHA1_HUMAN
Gene Name EPHA1
Synonyms
hEpha1; Tyrosine-protein kinase receptor EPH; Erythropoietin-producing hepatoma receptor; EPHT1; EPHT; EPH tyrosine kinase 1; EPH tyrosine kinase; EPH
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 49.8 nM [7]
Co-Target Name Ephrin type-A receptor 7 (EPHA7) Literature-reported Target
UniProt ID EPHA7_HUMAN
Gene Name EPHA7
Synonyms
hEK11; EPH-like kinase 11; EPH homology kinase 3; EK11; EHK3; EHK-3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 56.3 nM [1]
Co-Target Name Ephrin type-B receptor 1 (EPHB1) Literature-reported Target
UniProt ID EPHB1_HUMAN
Gene Name EPHB1
Synonyms
hEK6; Tyrosine-protein kinase receptor EPH-2; Neuronally-expressed EPH-related tyrosine kinase; EPHT2; EPH-like kinase 6; EPH tyrosine kinase 2; ELK; EK6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 60.3 nM [1]
Co-Target Name Doublecortin-like kinase 2 (DCLK2) Literature-reported Target
UniProt ID DCLK2_HUMAN
Gene Name DCLK2
Synonyms
Serine/threonine-protein kinase DCLK2; Doublecortin-like and CAM kinase-like 2; Doublecortin domain-containing protein 3B; DCK2; DCDC3B; DCAMKL2; CaMK-like CREB regulatory kinase 2; CLICK2; CLICK-II; CL2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 83.5 nM [1]
Co-Target Name PDZ binding kinase (PBK) Literature-reported Target
UniProt ID TOPK_HUMAN
Gene Name PBK
Synonyms
TOPK; T-LAK cell-originated protein kinase; Spermatogenesis-related protein kinase; SPK protein; PDZ-binding kinase; Nori-3; MAPKK-like protein kinase; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 83.9 nM [1]
Co-Target Name LIM domain kinase-2 (LIMK-2) Literature-reported Target
UniProt ID LIMK2_HUMAN
Gene Name LIMK2
Synonyms
LIMK-2; LIM domain kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 102 nM [1]
Co-Target Name HUMAN NIMA related kinase 9 (NEK9) Literature-reported Target
UniProt ID NEK9_HUMAN
Gene Name NEK9
Synonyms
Serine/threonine-protein kinase Nek9; NimA-related protein kinase 9; NimA-related kinase 8; Never in mitosis A-related kinase 9; Nercc1 kinase; Nek8
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 131 nM [1]
Co-Target Name Ephrin type-A receptor 8 (EPHA8) Literature-reported Target
UniProt ID EPHA8_HUMAN
Gene Name EPHA8
Synonyms
hEK3; Tyrosine-protein kinase receptor EEK; KIAA1459; EPH-like kinase 3; EPH- and ELK-related kinase; EK3; EEK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 137 nM [1]
Co-Target Name Doublecortin-like kinase 1 (DCLK1) Literature-reported Target
UniProt ID DCLK1_HUMAN
Gene Name DCLK1
Synonyms
Serine/threonine-protein kinase DCLK1; KIAA0369; Doublecortin-like and CAM kinase-like 1; Doublecortin domain-containing protein 3A; DCDC3A; DCAMKL1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 173 nM [1]
Co-Target Name SRSF protein kinase 2 (SRPK2) Literature-reported Target
UniProt ID SRPK2_HUMAN
Gene Name SRPK2
Synonyms
Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2; SFRS protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 227 nM [1]
Co-Target Name TGF-beta-stimulated factor 1 (STK16) Literature-reported Target
UniProt ID STK16_HUMAN
Gene Name STK16
Synonyms
hPSK; Tyrosine-protein kinase STK16; TSF1; TSF-1; Serine/threonine-protein kinase 16; Protein kinase PKL12; PKL12; Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK1; MPSK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 235 nM [1]
Co-Target Name Testis-specific kinase 1 (TESK1) Literature-reported Target
UniProt ID TESK1_HUMAN
Gene Name TESK1
Synonyms
Testicular protein kinase 1; Dual specificity testis-specific protein kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 261 nM [1]
Co-Target Name NIMA-related kinase 2 (NEK2) Literature-reported Target
UniProt ID NEK2_HUMAN
Gene Name NEK2
Synonyms
Serine/threonine-protein kinase Nek2; NimA-related protein kinase 2; NimA-like protein kinase 1; Never in mitosis A-related kinase 2; NLK1; NEK2A; HSPK 21
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 345 nM [1]
Co-Target Name Apoptosis signal-regulating kinase 2 (MAP3K6) Literature-reported Target
UniProt ID M3K6_HUMAN
Gene Name MAP3K6
Synonyms
MAP3K6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 475 nM [1]
Co-Target Name Homeodomain interacting protein kinase 2 (HIPK2) Literature-reported Target
UniProt ID HIPK2_HUMAN
Gene Name HIPK2
Synonyms
hHIPk2; Homeodomain-interacting protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 585 nM [1]
Co-Target Name Beta-adrenergic receptor kinase 2 (ADRBK2) Literature-reported Target
UniProt ID ARBK2_HUMAN
Gene Name GRK3
Synonyms
G-protein-coupled receptor kinase 3; Beta-ARK-2; BARK2; ADRBK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 850 nM [1]
Co-Target Name CaM kinase II delta (CAMK2D) Co-Target
UniProt ID KCC2D_HUMAN
Gene Name CAMK2D
Synonyms
Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.0311 nM [1]
Co-Target Name Testis-specific serine/threonine-protein kinase 1 (TSSK1B) Co-Target
UniProt ID TSSK1_HUMAN
Gene Name TSSK1B
Synonyms
TSK-1; TSK1; TSSK-1; Testis-specific kinase 1; Serine/threonine-protein kinase 22A
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.052 nM [1]
Co-Target Name CaM kinase II alpha (CAMK2A) Co-Target
UniProt ID KCC2A_HUMAN
Gene Name CAMK2A
Synonyms
Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.0635 nM [1]
Co-Target Name CaM kinase II beta (CAMK2B) Co-Target
UniProt ID KCC2B_HUMAN
Gene Name CAMK2B
Synonyms
Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.07 nM [3]
Co-Target Name MAP/microtubule affinity-regulating kinase 4 (MARK4) Co-Target
UniProt ID MARK4_HUMAN
Gene Name MARK4
Synonyms
MAP/microtubule affinity-regulating kinase-like 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.114 nM [1]
Co-Target Name CaM kinase I delta (CAMK1D) Co-Target
UniProt ID KCC1D_HUMAN
Gene Name CAMK1D
Synonyms
Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.298 nM [1]
Co-Target Name Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) Co-Target
UniProt ID M4K5_HUMAN
Gene Name MAP4K5
Synonyms
Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.309 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 3 (PAK3) Co-Target
UniProt ID PAK3_HUMAN
Gene Name PAK3
Synonyms
Beta-PAK; Oligophrenin-3; p21-activated kinase 3; PAK-3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.343 nM [1]
Co-Target Name CaM kinase II gamma (CAMK2G) Co-Target
UniProt ID KCC2G_HUMAN
Gene Name CAMK2G
Synonyms
Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.387 nM [1]
Co-Target Name Cyclin dependent kinase 2-Cyclin A2 complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA2_HUMAN
Gene Name CDK2-CCNA2
Representative Drug(s) Staurosporine Drug Info IC50 = 0.4 nM [44]
Co-Target Name Serine/threonine-protein kinase MST2 (STK3) Co-Target
UniProt ID STK3_HUMAN
Gene Name STK3
Synonyms
Serine/threonine-protein kinase 3; Mammalian STE20-like protein kinase 2; MST-2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.41 nM [4]
Co-Target Name Serine/threonine-protein kinase MARK1 (MARK1) Co-Target
UniProt ID MARK1_HUMAN
Gene Name MARK1
Synonyms
MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.417 nM [1]
Co-Target Name Inhibitor of nuclear factor kappa B kinase epsilon (IKBKE) Co-Target
UniProt ID IKKE_HUMAN
Gene Name IKBKE
Synonyms
Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.439 nM [1]
Co-Target Name Misshapen-like kinase 1 (MINK1) Co-Target
UniProt ID MINK1_HUMAN
Gene Name MINK1
Synonyms
GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.451 nM [1]
Co-Target Name Phosphorylase kinase (PHK) Co-Target
UniProt ID KPB1_HUMAN; KPB2_HUMAN; KPBB_HUMAN; PHKG1_HUMAN; PHKG2_HUMAN
Gene Name PHKA1; PHKA2; PHKB; PHKG1; PHKG2
Representative Drug(s) Staurosporine Drug Info IC50 = 0.5 nM [45]
Co-Target Name Death-associated protein kinase 1 (DAPK1) Co-Target
UniProt ID DAPK1_HUMAN
Gene Name DAPK1
Synonyms
DAP kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.5 nM [4]
Co-Target Name Cyclin dependent kinase 2-Cyclin A1 complex (CDK2-CCNA1) Co-Target
UniProt ID CDK2_HUMAN-CCNA1_HUMAN
Gene Name CDK2-CCNA1
Representative Drug(s) Staurosporine Drug Info IC50 = 0.5 nM [44]
Co-Target Name Serine/threonine-protein kinase MRCK gamma (CDC42BPG) Co-Target
UniProt ID MRCKG_HUMAN
Gene Name CDC42BPG
Synonyms
CDC42-binding protein kinase gamma; DMPK-like gamma; Myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCK gamma; MRCKG; Myotonic dystrophy protein kinase-like gamma; Myotonic dystrophy protein kinase-like alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.848 nM [1]
Co-Target Name Lysyl-tRNA synthetase (KARS1) Co-Target
UniProt ID SYK_HUMAN
Gene Name KARS1
Synonyms
Lysine--tRNA ligase; LysRS
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.86 nM [36]
Co-Target Name cAMP-dependent protein kinase (PKA) Co-Target
UniProt ID KAPCA_HUMAN; KAPCB_HUMAN; KAPCG_HUMAN
Gene Name PRKACA; PRKACB; PRKACG
Synonyms
PKA C
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 0.9 nM [10]
Co-Target Name Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) Co-Target
UniProt ID MP2K4_HUMAN
Gene Name MAP2K4
Synonyms
MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 1 nM [25]
Co-Target Name Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) Co-Target
UniProt ID MP2K6_HUMAN
Gene Name MAP2K6
Synonyms
MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 < 1 nM [25]
Co-Target Name Cyclin dependent kinase 2-G1/S specific cyclin E complex (CDK2-CCNE) Co-Target
UniProt ID CDK2_HUMAN-CCNE1_HUMAN/CCNE2_HUMAN
Gene Name CDK2-CCNE1/CCNE2
Representative Drug(s) Staurosporine Drug Info IC50 < 1 nM [12]
Co-Target Name cAMP-dependent protein kinase beta-1 (PRKACB) Co-Target
UniProt ID KAPCB_HUMAN
Gene Name PRKACB
Synonyms
cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.2 nM [1]
Co-Target Name Cyclin dependent kinase 5-CDK5 activator 1 complex (CDK5-CDK5R1) Co-Target
UniProt ID CDK5_HUMAN-CD5R1_HUMAN
Gene Name CDK5-CDK5R1
Representative Drug(s) Staurosporine Drug Info IC50 = 1.2 nM [44]
Co-Target Name Cyclin dependent kinase 1-G2/mitotic specific cyclin B1 complex (CDK1-CCNB1) Co-Target
UniProt ID CDK1_HUMAN-CCNB1_HUMAN
Gene Name CDK1-CCNB1
Representative Drug(s) Staurosporine Drug Info IC50 = 1.3 nM [46]
Co-Target Name Serine/threonine-protein kinase D2 (PRKD2) Co-Target
UniProt ID KPCD2_HUMAN
Gene Name PRKD2
Synonyms
nPKC-D2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.33 nM [1]
Co-Target Name Serine/threonine-protein kinase PRKX (PRKX) Co-Target
UniProt ID PRKX_HUMAN
Gene Name PRKX
Synonyms
cAMP-dependent protein kinase catalytic subunit PRKX; PrKX; Protein kinase X; Protein kinase X-linked; Protein kinase PKX1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.39 nM [1]
Co-Target Name Cyclin dependent kinase 2-Cyclin O complex (CDK2-CCNO) Co-Target
UniProt ID CDK2_HUMAN-CCNO_HUMAN
Gene Name CDK2-CCNO
Representative Drug(s) Staurosporine Drug Info IC50 = 1.46 nM [41]
Co-Target Name Cyclin dependent kinase 2-G1/S specific cyclin E1 complex (CDK2-CCNE1) Co-Target
UniProt ID CDK2_HUMAN-CCNE1_HUMAN
Gene Name CDK2-CCNE1
Representative Drug(s) Staurosporine Drug Info IC50 = 1.67 nM [1]
Co-Target Name Cyclin dependent kinase 1-Cyclin A2 complex (CDK1-CCNA2) Co-Target
UniProt ID CDK1_HUMAN-CCNA2_HUMAN
Gene Name CDK1-CCNA2
Representative Drug(s) Staurosporine Drug Info IC50 = 1.7 nM [44]
Co-Target Name Serine/threonine-protein kinase 25 (STK25) Co-Target
UniProt ID STK25_HUMAN
Gene Name STK25
Synonyms
Ste20-like kinase; Sterile 20/oxidant stress-response kinase 1; SOK-1; Ste20/oxidant stress response kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 1.9 nM [41]
Co-Target Name Cyclin dependent kinase 3-G1/Sspecific cyclin E1 complex (CDK3-CCNE1) Co-Target
UniProt ID CDK3_HUMAN-CCNE1_HUMAN
Gene Name CDK3-CCNE1
Representative Drug(s) Staurosporine Drug Info IC50 = 2.08 nM [41]
Co-Target Name Cyclin dependent kinase 1-G1/S specific Cyclin E1 complex (CDK1-CCNE) Co-Target
UniProt ID CDK1_HUMAN-CCNE1_HUMAN
Gene Name CDK1-CCNE1
Representative Drug(s) Staurosporine Drug Info IC50 = 2.17 nM [3]
Co-Target Name Ribosomal protein S6 kinase beta 2 (RPS6KB2) Co-Target
UniProt ID KS6B2_HUMAN
Gene Name RPS6KB2
Synonyms
Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.35 nM [1]
Co-Target Name Cyclin dependent kinase 1-G2/mitotic specific cyclin B complex (CDK1-CCNB) Co-Target
UniProt ID CDK1_HUMAN-CCNB1_HUMAN/CCNB2_HUMAN/CCNB3_HUMAN
Gene Name CDK1-CCNB1/CCNB2/CCNB3
Representative Drug(s) Staurosporine Drug Info IC50 = 2.52 nM [12]
Co-Target Name Phosphorylase kinase gamma 1 (PHKG1) Co-Target
UniProt ID PHKG1_HUMAN
Gene Name PHKG1
Synonyms
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; PHK-gamma-M; Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.58 nM [1]
Co-Target Name Serine/threonine-protein kinase ULK2 (ULK2) Co-Target
UniProt ID ULK2_HUMAN
Gene Name ULK2
Synonyms
Unc-51-like kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.67 nM [1]
Co-Target Name Serine/threonine-protein kinase MST4 (STK26) Co-Target
UniProt ID STK26_HUMAN
Gene Name STK26
Synonyms
Serine/threonine-protein kinase 26; MST3 and SOK1-related kinase; Mammalian STE20-like protein kinase 4; MST-4; STE20-like kinase MST4; Serine/threonine-protein kinase MASK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 2.87 nM [1]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D1 complex (CDK6-CCND1) Co-Target
UniProt ID CDK6_HUMAN-CCND1_HUMAN
Gene Name CDK6-CCND1
Representative Drug(s) Staurosporine Drug Info IC50 = 2.9 nM [44]
Co-Target Name CaM kinase I alpha (CAMK1) Co-Target
UniProt ID KCC1A_HUMAN
Gene Name CAMK1
Synonyms
Calcium/calmodulin-dependent protein kinase type 1; CaM kinase I; CaM-KI; CaMKI-alpha
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.02 nM [1]
Co-Target Name Pseudopodium-enriched atypical kinase 1 (PEAK1) Co-Target
UniProt ID PEAK1_HUMAN
Gene Name PEAK1
Synonyms
Inactive tyrosine-protein kinase PEAK1; Sugen kinase 269; Tyrosine-protein kinase SgK269
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.04 nM [1]
Co-Target Name Serine/threonine-protein kinase 24 (STK24) Co-Target
UniProt ID STK24_HUMAN
Gene Name STK24
Synonyms
Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.34 nM [41]
Co-Target Name Serine/threonine-protein kinase tousled-like 2 (TLK2) Co-Target
UniProt ID TLK2_HUMAN
Gene Name TLK2
Synonyms
HsHPK; PKU-alpha; Tousled-like kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 3.66 nM [1]
Co-Target Name Cyclin dependent kinase 9-Cyclin T2 complex (CDK9-CCNT2) Co-Target
UniProt ID CDK9_HUMAN-CCNT2_HUMAN
Gene Name CDK9-CCNT2
Representative Drug(s) Staurosporine Drug Info IC50 = 3.77 nM [1]
Co-Target Name Cyclin dependent kinase 2-Cyclin A complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA1_HUMAN/CCNA2_HUMAN
Gene Name CDK2-CCNA1/CCNA2
Representative Drug(s) Staurosporine Drug Info Ki = 4 nM [47]
Co-Target Name Serine/threonine-protein kinase MRCK beta (CDC42BPB) Co-Target
UniProt ID MRCKB_HUMAN
Gene Name CDC42BPB
Synonyms
CDC42-binding protein kinase beta; CDC42BP-beta; DMPK-like beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; MRCK beta; Myotonic dystrophy protein kinase-like beta
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.75 nM [1]
Co-Target Name CaM kinase I beta (PNCK) Co-Target
UniProt ID KCC1B_HUMAN
Gene Name PNCK
Synonyms
Calcium/calmodulin-dependent protein kinase type 1B; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 4.99 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 5 (PAK5) Co-Target
UniProt ID PAK5_HUMAN
Gene Name PAK5
Synonyms
p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.3 nM [1]
Co-Target Name CaM kinase I gamma (CAMK1G) Co-Target
UniProt ID KCC1G_HUMAN
Gene Name CAMK1G
Synonyms
Calcium/calmodulin-dependent protein kinase type 1G; CaM kinase IG; CaM-KI gamma; CaMKI gamma; CaMKIG; CaMK-like CREB kinase III; CLICK III
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.34 nM [1]
Co-Target Name G protein-coupled receptor kinase 7 (GRK7) Co-Target
UniProt ID GRK7_HUMAN
Gene Name GRK7
Synonyms
Rhodopsin kinase GRK7; G protein-coupled receptor kinase GRK7
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 5.96 nM [1]
Co-Target Name Cyclin dependent kinase 8-Cyclin C complex (CDK8-CCNC) Co-Target
UniProt ID CDK8_HUMAN-CCNC_HUMAN
Gene Name CDK8-CCNC
Representative Drug(s) Staurosporine Drug Info IC50 = 6 nM [48]
Co-Target Name Myosin IIIB (MYO3B) Co-Target
UniProt ID MYO3B_HUMAN
Gene Name MYO3B
Synonyms
Myosin-IIIb
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.4 nM [1]
Co-Target Name Cyclin dependent kinase 4-G1/S specific cyclin D1 complex (CDK4-CCND1) Co-Target
UniProt ID CDK4_HUMAN-CCND1_HUMAN
Gene Name CDK4-CCND1
Representative Drug(s) Staurosporine Drug Info IC50 = 6.6 nM [44]
Co-Target Name cAMP-dependent protein kinase gamma (PRKACG) Co-Target
UniProt ID KAPCG_HUMAN
Gene Name PRKACG
Synonyms
cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 6.8 nM [1]
Co-Target Name Testis-specific serine/threonine-protein kinase 3 (TSSK3) Co-Target
UniProt ID TSSK3_HUMAN
Gene Name TSSK3
Synonyms
TSK-3; TSSK-3; Testis-specific kinase 3; Serine/threonine-protein kinase 22C
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 7.01 nM [1]
Co-Target Name Death-associated protein kinase 2 (DAPK2) Co-Target
UniProt ID DAPK2_HUMAN
Gene Name DAPK2
Synonyms
DAP kinase 2; DAP-kinase-related protein 1; DRP-1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 7.25 nM [1]
Co-Target Name Mitogen-activated protein kinase 15 (MAPK15) Co-Target
UniProt ID MK15_HUMAN
Gene Name MAPK15
Synonyms
MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 7.3 nM [3]
Co-Target Name SNF-related serine/threonine-protein kinase (SNRK) Co-Target
UniProt ID SNRK_HUMAN
Gene Name SNRK
Synonyms
SNF1-related kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 8.01 nM [1]
Co-Target Name Serine/threonine-protein kinase 10 (STK10) Co-Target
UniProt ID STK10_HUMAN
Gene Name STK10
Synonyms
Lymphocyte-oriented kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 9.01 nM [1]
Co-Target Name Ribosomal protein S6 kinase alpha 4 (RPS6KA4) Co-Target
UniProt ID KS6A4_HUMAN
Gene Name RPS6KA4
Synonyms
Ribosomal protein S6 kinase alpha-4; S6K-alpha-4; 90 kDa ribosomal protein S6 kinase 4; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; RSKB
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11.3 nM [1]
Co-Target Name Serine/threonine-protein kinase TAO2 (TAOK2) Co-Target
UniProt ID TAOK2_HUMAN
Gene Name TAOK2
Synonyms
Kinase from chicken homolog C; hKFC-C; Prostate-derived sterile 20-like kinase 1; PSK-1; PSK1; Prostate-derived STE20-like kinase 1; Thousand and one amino acid protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 11.7 nM [1]
Co-Target Name Serine/threonine-protein kinase LATS1 (LATS1) Co-Target
UniProt ID LATS1_HUMAN
Gene Name LATS1
Synonyms
Large tumor suppressor homolog 1; WARTS protein kinase; h-warts
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 12.8 nM [1]
Co-Target Name Cyclin dependent kinase 9-Cyclin K complex (CDK9-CCNK) Co-Target
UniProt ID CDK9_HUMAN-CCNK_HUMAN
Gene Name CDK9-CCNK
Representative Drug(s) Staurosporine Drug Info IC50 = 13 nM [44]
Co-Target Name Insulin receptor-related protein (INSRR) Co-Target
UniProt ID INSRR_HUMAN
Gene Name INSRR
Synonyms
IRR; IR-related receptor
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 15 nM [1]
Co-Target Name Cyclin dependent kinase 6-G1/S specific cyclin D3 complex (CDK6-CCND2) Co-Target
UniProt ID CDK6_HUMAN-CCND3_HUMAN
Gene Name CDK6-CCND3
Representative Drug(s) Staurosporine Drug Info IC50 = 15.4 nM [1]
Co-Target Name Cyclin dependent kinase 17-Cyclin Y complex (CDK17-CCNY) Co-Target
UniProt ID CDK17_HUMAN-CCNY_HUMAN
Gene Name CDK17-CCNY
Representative Drug(s) Staurosporine Drug Info IC50 = 16.3 nM [1]
Co-Target Name Serine/threonine-protein kinase Sgk2 (SGK2) Co-Target
UniProt ID SGK2_HUMAN
Gene Name SGK2
Synonyms
Serum/glucocorticoid-regulated kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 16.5 nM [1]
Co-Target Name Tyrosine-protein kinase FRK (FRK) Co-Target
UniProt ID FRK_HUMAN
Gene Name FRK
Synonyms
FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 17 nM [1]
Co-Target Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) Co-Target
UniProt ID MP2K3_HUMAN
Gene Name MAP2K3
Synonyms
MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 17.2 nM [1]
Co-Target Name Serine/threonine-protein kinase haspin (HASPIN) Co-Target
UniProt ID HASP_HUMAN
Gene Name HASPIN
Synonyms
Germ cell-specific gene 2 protein; H-haspin; Haploid germ cell-specific nuclear protein kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 19 nM [41]
Co-Target Name Serine/threonine-protein kinase tousled-like 1 (TLK1) Co-Target
UniProt ID TLK1_HUMAN
Gene Name TLK1
Synonyms
PKU-beta; Tousled-like kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 21.7 nM [1]
Co-Target Name Cyclin dependent kinase 16-Cyclin Y complex (CDK16-CCNY) Co-Target
UniProt ID CDK16_HUMAN-CCNY_HUMAN
Gene Name CDK16-CCNY
Representative Drug(s) Staurosporine Drug Info IC50 = 24 nM [1]
Co-Target Name Serine/threonine-protein kinase 17B (STK17B) Co-Target
UniProt ID ST17B_HUMAN
Gene Name STK17B
Synonyms
DAP kinase-related apoptosis-inducing protein kinase 2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 25.8 nM [23]
Co-Target Name Serine/threonine-protein kinase MAK (MAK) Co-Target
UniProt ID MAK_HUMAN
Gene Name MAK
Synonyms
Male germ cell-associated kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 28.7 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 6 (PAK6) Co-Target
UniProt ID PAK6_HUMAN
Gene Name PAK6
Synonyms
PAK-5; p21-activated kinase 6; PAK-6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 31 nM [1]
Co-Target Name TGF-beta-activated kinase 1-binding protein 1 (TAB1) Co-Target
UniProt ID TAB1_HUMAN
Gene Name TAB1
Synonyms
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAK1-binding protein 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 35 nM [4]
Co-Target Name Cyclin dependent kinase 4-G1/S-specific cyclin-D3 complex (CDK4-CCND3) Co-Target
UniProt ID CDK4_HUMAN-CCND3_HUMAN
Gene Name CDK4-CCND3
Representative Drug(s) Staurosporine Drug Info IC50 = 37.1 nM [1]
Co-Target Name Serine/threonine-protein kinase ICK (CILK1) Co-Target
UniProt ID CILK1_HUMAN
Gene Name CILK1
Synonyms
Ciliogenesis associated kinase 1; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 41.06 nM [3]
Co-Target Name Myosin IIIA (MYO3A) Co-Target
UniProt ID MYO3A_HUMAN
Gene Name MYO3A
Synonyms
Myosin-IIIa
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 44.8 nM [1]
Co-Target Name CDC7-related kinase-Protein DBF4 homolog A (CDC7-DBF4) Co-Target
UniProt ID CDC7_HUMAN; DBF4A_HUMAN
Gene Name CDC7; DBF4
Synonyms
Cell division cycle 7 related protein kinase-Activator of S phase kinase; Cell division cycle 7 related protein kinase-DBF4-type zinc finger-containing protein 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 46.3 nM [1]
Co-Target Name Cyclin dependent kinase 18-Cyclin Y complex (CDK18-CCNY) Co-Target
UniProt ID CDK18_HUMAN-CCNY_HUMAN
Gene Name CDK18-CCNY
Representative Drug(s) Staurosporine Drug Info IC50 = 51.1 nM [1]
Co-Target Name Myosin light chain kinase 4 (MYLK4) Co-Target
UniProt ID MYLK4_HUMAN
Gene Name MYLK4
Synonyms
Myosin light chain kinase family member 4; Sugen kinase 85; SgK085
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 52.9 nM [1]
Co-Target Name Cyclin dependent kinase 12-Cyclin K complex (CDK12-CCNK) Co-Target
UniProt ID CDK12_HUMAN-CCNK_HUMAN
Gene Name CDK12-CCNK
Representative Drug(s) Staurosporine Drug Info IC50 = 53 nM [49]
Co-Target Name Cyclin dependent kinase 13-Cyclin K complex (CDK13-CCNK) Co-Target
UniProt ID CDK13_HUMAN-CCNK_HUMAN
Gene Name CDK13-CCNK
Representative Drug(s) Staurosporine Drug Info IC50 = 57 nM [49]
Co-Target Name Rhodopsin kinase (GRK1) Co-Target
UniProt ID GRK1_HUMAN
Gene Name GRK1
Synonyms
G protein-coupled receptor kinase 1; Rhodopsin kinase GRK1; RK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 57.8 nM [1]
Co-Target Name Protein odd-skipped-related 1 (OSR1) Co-Target
UniProt ID OSR1_HUMAN
Gene Name OSR1
Representative Drug(s) Staurosporine Drug Info IC50 = 61.3 nM [1]
Co-Target Name G protein-coupled receptor kinase 6 (GRK6) Co-Target
UniProt ID GRK6_HUMAN
Gene Name GRK6
Synonyms
G protein-coupled receptor kinase GRK6
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 61.7 nM [1]
Co-Target Name Dual serine/threonine and tyrosine protein kinase (DSTYK) Co-Target
UniProt ID DUSTY_HUMAN
Gene Name DSTYK
Synonyms
Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 65.2 nM [1]
Co-Target Name Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2) Co-Target
UniProt ID ERN2_HUMAN
Gene Name ERN2
Synonyms
Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 65.8 nM [1]
Co-Target Name Retinoblastoma-associated protein (RB1) Co-Target
UniProt ID RB_HUMAN
Gene Name RB1
Synonyms
p110-RB1; p105-Rb; pRb; Rb; pp110
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 66 nM [50]
Co-Target Name Serine/threonine-protein kinase 11 (STK11) Co-Target
UniProt ID STK11_HUMAN
Gene Name STK11
Synonyms
Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 70.9 nM [1]
Co-Target Name Serine/threonine-protein kinase Sgk3 (SGK3) Co-Target
UniProt ID SGK3_HUMAN
Gene Name SGK3
Synonyms
Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 76.5 nM [1]
Co-Target Name CDK7-Cyclin H-CDK activating kinase assembly factor MAT1 complex (CDK7-CCNH-MNAT1) Co-Target
UniProt ID CDK7_HUMAN-CCNH_HUMAN-MAT1_HUMAN
Gene Name CDK7-CCNH-MNAT1
Representative Drug(s) Staurosporine Drug Info IC50 = 76.6 nM [1]
Co-Target Name Serine/threonine protein kinase NLK (NLK) Co-Target
UniProt ID NLK_HUMAN
Gene Name NLK
Synonyms
Serine/threonine-protein kinase NLK; Nemo-like kinase; Protein LAK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 77.8 nM [1]
Co-Target Name Serine/threonine-protein kinase Nek4 (NEK4) Co-Target
UniProt ID NEK4_HUMAN
Gene Name NEK4
Synonyms
Never in mitosis A-related kinase 4; NimA-related protein kinase 4; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase NRK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 96 nM [1]
Co-Target Name Serine/threonine-protein kinase Nek5 (NEK5) Co-Target
UniProt ID NEK5_HUMAN
Gene Name NEK5
Synonyms
Never in mitosis A-related kinase 5; NimA-related protein kinase 5
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 96.5 nM [1]
Co-Target Name Serine/threonine-protein kinase SBK1 (SBK1) Co-Target
UniProt ID SBK1_HUMAN
Gene Name SBK1
Synonyms
SH3-binding kinase 1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 99.8 nM [1]
Co-Target Name Cyclin dependent kinase 14-Cyclin Y complex (CDK14-CCNY) Co-Target
UniProt ID CDK14_HUMAN-CCNY_HUMAN
Gene Name CDK14-CCNY
Representative Drug(s) Staurosporine Drug Info IC50 = 101 nM [1]
Co-Target Name Myotonin-protein kinase (DMPK) Co-Target
UniProt ID DMPK_HUMAN
Gene Name DMPK
Synonyms
MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 105 nM [1]
Co-Target Name G protein-coupled receptor kinase 4 (GRK4) Co-Target
UniProt ID GRK4_HUMAN
Gene Name GRK4
Synonyms
G protein-coupled receptor kinase GRK4; ITI1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 113 nM [1]
Co-Target Name Myosin light chain kinase 3 (MYLK3) Co-Target
UniProt ID MYLK3_HUMAN
Gene Name MYLK3
Synonyms
Cardiac-MyBP-C-associated Ca/CaM kinase; Cardiac-MLCK
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 129 nM [1]
Co-Target Name Serine/threonine-protein kinase NIM1 (NIM1K) Co-Target
UniProt ID NIM1_HUMAN
Gene Name NIM1K
Synonyms
NIM1 serine/threonine-protein kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 129 nM [1]
Co-Target Name CaM kinase IV (CAMK4) Co-Target
UniProt ID KCC4_HUMAN
Gene Name CAMK4
Synonyms
Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 157 nM [1]
Co-Target Name MAP kinase p38 delta (MAPK13) Co-Target
UniProt ID MK13_HUMAN
Gene Name MAPK13
Synonyms
Mitogen-activated protein kinase 13; MAP kinase 13; MAPK 13; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 160 nM [1]
Co-Target Name Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) Co-Target
UniProt ID M3K12_HUMAN
Gene Name MAP3K12
Synonyms
Dual leucine zipper bearing kinase; DLK; Leucine-zipper protein kinase; ZPK; MAPK-upstream kinase; MUK; Mixed lineage kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 180 nM [1]
Co-Target Name Testis-specific serine/threonine-protein kinase 6 (TSSK6) Co-Target
UniProt ID TSSK6_HUMAN
Gene Name TSSK6
Synonyms
TSK-6; TSSK-6; Testis-specific kinase 6; Cancer/testis antigen 72; CT72; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 193 nM [1]
Co-Target Name Serine/threonine-protein kinase PLK3 (PLK3) Co-Target
UniProt ID PLK3_HUMAN
Gene Name PLK3
Synonyms
Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Proliferation-related kinase
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 224 nM [1]
Co-Target Name Homeodomain-interacting protein kinase 4 (HIPK4) Co-Target
UniProt ID HIPK4_HUMAN
Gene Name HIPK4
Representative Drug(s) Staurosporine Drug Info IC50 = 314 nM [1]
Co-Target Name Serine/threonine-protein kinase RIPK2 (RIPK2) Co-Target
UniProt ID RIPK2_HUMAN
Gene Name RIPK2
Synonyms
Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 317 nM [1]
Co-Target Name Serine/threonine-protein kinase 32C (STK32C) Co-Target
UniProt ID ST32C_HUMAN
Gene Name STK32C
Synonyms
PKE; Yet another novel kinase 3
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 325 nM [1]
Co-Target Name Tyrosine-protein kinase CTK (MATK) Co-Target
UniProt ID MATK_HUMAN
Gene Name MATK
Synonyms
Megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 492 nM [1]
Co-Target Name Homeodomain-interacting protein kinase 3 (HIPK3) Co-Target
UniProt ID HIPK3_HUMAN
Gene Name HIPK3
Synonyms
Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homolog of protein kinase YAK1
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 710 nM [1]
Co-Target Name Serine/threonine-protein kinase Nek11 (NEK11) Co-Target
UniProt ID NEK11_HUMAN
Gene Name NEK11
Synonyms
Never in mitosis A-related kinase 11; NimA-related protein kinase 11
    Click to Show/Hide
Representative Drug(s) Staurosporine Drug Info IC50 = 752 nM [1]
Co-Target Name Cyclin dependent kinase 7-Cyclin H complex (CDK7-CCNH) Co-Target
UniProt ID CDK7_HUMAN-CCNH_HUMAN
Gene Name CDK7-CCNH
Representative Drug(s) Staurosporine Drug Info IC50 = 910 nM [44]
References  Top
REF 1 ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. Eur J Med Chem. 2019 Jan 1;161:456-467.
REF 2 Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4720-3.
REF 3 Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders. Eur J Med Chem. 2017 Dec 1;141:657-675.
REF 4 Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem. 2009 May 28;52(10):3191-204.
REF 5 Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly. Bioorg Med Chem Lett. 2012 Jan 1;22(1):591-6.
REF 6 Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping. J Med Chem. 2017 Jun 8;60(11):4636-56.
REF 7 Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors. Bioorg Med Chem. 2016 Aug 15;24(16):3483-93.
REF 8 Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design. J Med Chem. 2017 Nov 22;60(22):9205-9221.
REF 9 Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors. Eur J Med Chem. 2011 Sep;46(9):4311-23.
REF 10 Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4163-8.
REF 11 Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2. Bioorg Med Chem. 2011 Sep 15;19(18):5342-51.
REF 12 Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors. Eur J Med Chem. 2015 Sep 18;102:600-10.
REF 13 Structural basis for the inhibitor recognition of human Lyn kinase domain. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6557-60.
REF 14 Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53.
REF 15 Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases. J Med Chem. 2004 Nov 18;47(24):5894-911.
REF 16 Design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs. Eur J Med Chem. 2017 Feb 15;127:442-58.
REF 17 Novel 8-arylated purines as inhibitors of glycogen synthase kinase. Eur J Med Chem. 2010 Aug;45(8):3389-93.
REF 18 Design, synthesis, and biological activity of phenyl-pyrazole derivatives as BCR-ABL kinase inhibitors. Bioorg Med Chem. 2015 Jul 1;23(13):3147-52.
REF 19 Molecular docking study on anticancer activity of plant-derived natural products. Med Chem Res. 2009 Jul 28;19:817-35.
REF 20 Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7.
REF 21 From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem. 2009 Apr 9;52(7):1853-63.
REF 22 Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61. J Nat Prod. 2018 Apr 27;81(4):949-956.
REF 23 Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3beta inhibitors and neuroprotective agents. Bioorg Med Chem. 2015 Mar 1;23(5):1179-88.
REF 24 Purpuroines A-J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases. Bioorg Med Chem. 2012 Dec 15;20(24):6924-8.
REF 25 Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyro... J Med Chem. 2002 Aug 15;45(17):3772-93.
REF 26 Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors. Bioorg Med Chem. 2014 Sep 1;22(17):4855-66.
REF 27 The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.
REF 28 Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy. Eur J Med Chem. 2017 May 5;131:1-13.
REF 29 Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3835-9.
REF 30 Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem. 2017 Apr 1;25(7):2156-2166.
REF 31 Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32.
REF 32 Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors. Eur J Med Chem. 2016 Jul 19;117:47-58.
REF 33 Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J Med Chem. 2009 Apr 9;52(7):1814-27.
REF 34 Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties. Bioorg Med Chem Lett. 1995 Jan 5;5(1):55-60.
REF 35 Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. J Med Chem. 2014 Jun 26;57(12):5011-22.
REF 36 Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. J Nat Prod. 2018 Apr 27;81(4):998-1006.
REF 37 Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2. Eur J Med Chem. 2015 Oct 20;103:29-43.
REF 38 Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-beta type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem. 2014 May 22;57(10):4213-38.
REF 39 Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14.
REF 40 Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum. J Nat Prod. 2014 Jan 24;77(1):49-56.
REF 41 Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone. Eur J Med Chem. 2019 Feb 1;163:453-480.
REF 42 Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85.
REF 43 Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IkappaB kinase-beta. Eur J Med Chem. 2011 Apr;46(4):1245-53.
REF 44 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem. 2013 May 23;56(10):3768-82.
REF 45 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
REF 46 Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells. Bioorg Med Chem. 2011 Nov 15;19(22):6760-7.
REF 47 Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. J Med Chem. 2013 Feb 14;56(3):660-70.
REF 48 Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening. Eur J Med Chem. 2017 Mar 31;129:275-286.
REF 49 Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7710-7728.
REF 50 Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors. Eur J Med Chem. 2017 Jul 7;134:366-378.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.