Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86734 | Target Info | |||
| Target Name | Glutaminase (GLS) | ||||
| Synonyms |
L-glutamine amidohydrolase; Glutaminase, mitochondrial; GLS
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| Target Type | Clinical trial Target | ||||
| Gene Name | GLS; GLS2 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | L-glutamine amidohydrolase (GLS) | Co-Target | ||||
| UniProt ID | GLSK_HUMAN | |||||
| Gene Name | GLS | |||||
| Synonyms |
Glutaminase kidney isoform, mitochondrial; GLS; K-glutaminase
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| Representative Drug(s) | CB-839 | Drug Info | IC50 = 2 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2019 Jan 24;62(2):589-603. | ||||
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