Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T86052 Target Info
Target Name Telomerase reverse transcriptase (TERT)
Synonyms
Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name TERT
Biochemical Class Kinase
UniProt ID
TERT_HUMAN
Co-Targets of This Target  Top
Co-Target Name Acetylcholinesterase (AChE) Successful Target
UniProt ID ACES_HUMAN
Gene Name ACHE
Synonyms
YT; N-ACHE; ARACHE
    Click to Show/Hide
Representative Drug(s) Berberine Drug Info IC50 = 40 nM Click to Show More [1]
2 Berberine Drug Info IC50 = 100 nM [2]
Co-Target Name Cytochrome P450 1B1 (CYP1B1) Clinical trial Target
UniProt ID CP1B1_HUMAN
Gene Name CYP1B1
Synonyms
CYPIB1
    Click to Show/Hide
Representative Drug(s) Berberine Drug Info Ki = 44 nM [3]
References  Top
REF 1 Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7.
REF 2 Isolation of cholinesterase and beta-secretase 1 inhibiting compounds from Lycopodiella cernua. Bioorg Med Chem. 2015 Jul 1;23(13):3126-34.
REF 3 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.