Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T84726 Target Info
Target Name Rho-associated protein kinase (ROCK)
Synonyms
Rho-associated, coiled-coil-containing protein kinase; Rho associated protein kinase
    Click to Show/Hide
Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Clinical trial Target
UniProt ID AKT1_HUMAN
Gene Name AKT1
Synonyms
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
    Click to Show/Hide
Representative Drug(s) AT13148 Drug Info IC50 = 38 nM [1]
Co-Target Name RAC-gamma serine/threonine-protein kinase (AKT3) Clinical trial Target
UniProt ID AKT3_HUMAN
Gene Name AKT3
Synonyms
STK-2; RAC-PK-gamma; Protein kinase B gamma; Protein kinase Akt-3; PKBG; PKB gamma
    Click to Show/Hide
Representative Drug(s) AT13148 Drug Info IC50 = 50 nM [1]
Co-Target Name HUMAN protein kinase cAMP-activated catalytic subunit alpha (PRKACA) Literature-reported Target
UniProt ID KAPCA_HUMAN
Gene Name PRKACA
Synonyms
PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha
    Click to Show/Hide
Representative Drug(s) AT13148 Drug Info IC50 < 10 nM [1]
Co-Target Name RAC-beta serine/threonine-protein kinase (AKT2) Literature-reported Target
UniProt ID AKT2_HUMAN
Gene Name AKT2
Synonyms
RAC-PK-beta; Protein kinase B beta; Protein kinase Akt-2; PKB beta
    Click to Show/Hide
Representative Drug(s) AT13148 Drug Info IC50 = 402 nM [1]
Co-Target Name Protein kinase N2 (PKN2) Literature-reported Target
UniProt ID PKN2_HUMAN
Gene Name PKN2
Synonyms
Serine/threonine-protein kinase N2; Protein-kinase C-related kinase 2; Protein kinase C-like 2; PRKCL2; PRK2; PKN gamma
    Click to Show/Hide
Representative Drug(s) Ximelegatran Drug Info IC50 = 600 nM [2]
References  Top
REF 1 Recent progress towards clinically relevant ATP-competitive Akt inhibitors. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2838-48.
REF 2 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.