Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84591 | Target Info | |||
| Target Name | Guanine nucleotide exchange factor (GNEF) | ||||
| Synonyms |
eIF-2B GDP-GTP exchange factor; Translation initiation factor eIF-2B; EIF2B
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| Target Type | Clinical trial Target | ||||
| Gene Name | EIF2B1; EIF2B2 | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | S-mephenytoin 4-hydroxylase (CYP2C9) | Successful Target | ||||
| UniProt ID | CP2C9_HUMAN | |||||
| Gene Name | CYP2C9 | |||||
| Synonyms |
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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| Representative Drug(s) | Plinabulin | Drug Info | IC50 = 530 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | In vitro and in vivo pharmacokinetic and pharmacodynamic study of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent. Bioorg Med Chem. 2018 Sep 1;26(16):4687-4692. | ||||
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