Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83386 | Target Info | |||
| Target Name | Folate receptor alpha (FOLR1) | ||||
| Synonyms |
Ovarian tumorassociated antigen MOv18; KB cells FBP; Folate receptor, adult; Folate receptor 1; FRalpha; FOLR1; Adult folatebinding protein
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| Target Type | Successful Target | ||||
| Gene Name | FOLR1 | ||||
| Biochemical Class | Folate receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Dihydrofolate reductase (DHFR) | Successful Target | ||||
| UniProt ID | DYR_HUMAN | |||||
| Gene Name | DHFR | |||||
| Synonyms |
DYR; DHFRP1
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| Representative Drug(s) | Pyrimethamine | Drug Info | Ki = 8 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. J Med Chem. 2002 Mar 14;45(6):1244-52. | ||||
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