Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83059 | Target Info | |||
| Target Name | Tankyrase (TNKS) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Poly [ADP-ribose] polymerase 1 (PARP1) | Successful Target | ||||
| UniProt ID | PARP1_HUMAN | |||||
| Gene Name | PARP1 | |||||
| Synonyms |
Protein poly-ADP-ribosyltransferase PARP1; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PPOL; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
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| Representative Drug(s) | BGB-290 | Drug Info | IC50 = 0.9 nM | [1] | ||
| Co-Target Name | Poly [ADP-ribose] polymerase 2 (PARP2) | Patented-recorded Target | ||||
| UniProt ID | PARP2_HUMAN | |||||
| Gene Name | PARP2 | |||||
| Synonyms |
pADPRT-2; hPARP-2; Protein poly-ADP-ribosyltransferase PARP2; Poly[ADP-ribose] synthase 2; PARP-2; NAD(+) ADP-ribosyltransferase 2; DNA ADP-ribosyltransferase PARP2; ARTD2; ADPRTL2; ADPRT2; ADPRT-2; ADP-ribosyltransferase diphtheria toxin-like 2
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| Representative Drug(s) | BGB-290 | Drug Info | IC50 = 0.5 nM | [1] | ||
| Co-Target Name | Poly [ADP-ribose] polymerase 3 (PARP3) | Patented-recorded Target | ||||
| UniProt ID | PARP3_HUMAN | |||||
| Gene Name | PARP3 | |||||
| Synonyms |
pADPRT-3; hPARP-3; Protein mono-ADP-ribosyltransferase PARP3; Poly[ADP-ribose] synthase 3; PARP-3; NAD(+) ADP-ribosyltransferase 3; IRT1; DNA ADP-ribosyltransferase PARP3; ARTD3; ADPRTL3; ADPRT3; ADPRT-3; ADP-ribosyltransferase diphtheria toxin-like 3
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| Representative Drug(s) | BGB-290 | Drug Info | IC50 = 185 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9260440B2, Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors | ||||
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