Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T81892 | Target Info | |||
Target Name | XIAP messenger RNA (XIAP mRNA) | ||||
Synonyms |
hILP (mRNA); hIAP3 (mRNA); hIAP-3 (mRNA); Xlinked IAP (mRNA); X-linked IAP (mRNA); RING-type E3 ubiquitin transferase XIAP (mRNA); Inhibitor of apoptosis protein 3 (mRNA); ILP (mRNA); IAPlike protein (mRNA); IAP3 (mRNA); IAP-like protein (mRNA); IAP-3 (mRNA); E3 ubiquitinprotein ligase XIAP (mRNA); E3 ubiquitin-protein ligase XIAP (mRNA); Baculoviral IAP repeatcontaining protein 4 (mRNA); Baculoviral IAP repeat-containing protein 4 (mRNA); BIRC4 (mRNA); API3 (mRNA)
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Target Type | Clinical trial Target | ||||
Gene Name | XIAP | ||||
Biochemical Class | mRNA target | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Cellular inhibitor of apoptosis 1 (BIRC2) | Clinical trial Target | ||||
UniProt ID | BIRC2_HUMAN | |||||
Gene Name | BIRC2 | |||||
Synonyms |
hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
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Representative Drug(s) | ASTX660 | Drug Info | IC50 = 0.22 nM | [1] |
References | Top | ||||
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REF 1 | A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660). J Med Chem. 2018 Aug 23;61(16):7314-7329. |
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