Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76910 | Target Info | |||
| Target Name | Glycogen synthase kinase-3 alpha (GSK-3A) | ||||
| Synonyms |
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
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| Target Type | Successful Target | ||||
| Gene Name | GSK3A | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | ||||
| UniProt ID | GSK3B_HUMAN | |||||
| Gene Name | GSK3B | |||||
| Synonyms |
Serine/threonine-protein kinase GSK3B; GSK-3 beta
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| Representative Drug(s) | LY2090314 | Drug Info | IC50 = 0.7 nM | [1] | ||
| Co-Target Name | Protein kinase C beta (PRKCB) | Clinical trial Target | ||||
| UniProt ID | KPCB_HUMAN | |||||
| Gene Name | PRKCB | |||||
| Synonyms |
Protein kinase C beta type; PRKCB1; PKCB; PKC-beta; PKC-B
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| Representative Drug(s) | LY2090314 | Drug Info | IC50 = 420 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3. J Med Chem. 2004 Jul 29;47(16):3934-7. | ||||
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