Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75888 | Target Info | |||
| Target Name | Carnitine O-palmitoyltransferase I (CPT1B) | ||||
| Synonyms |
KIAA1670; Carnitine palmitoyltransferase I-like protein; Carnitine palmitoyltransferase I; Carnitine palmitoyltransferase 1B; Carnitine palmitoyl-transferase I; Carnitine o-palmitoyltransferase-1; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine O-palmitoyltransferase 1, muscle isoform; CPTI-M; CPTI-L; CPT1-M; CPT-1; CPT I; CPT
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| Target Type | Successful Target | ||||
| Gene Name | CPT1B | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Muscarinic acetylcholine receptor M4 (CHRM4) | Successful Target | ||||
| UniProt ID | ACM4_HUMAN | |||||
| Gene Name | CHRM4 | |||||
| Synonyms |
M4 receptor; CHRM4
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| Representative Drug(s) | Perhexiline | Drug Info | Ki = 500.9 nM | [1] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M1 (CHRM1) | Successful Target | ||||
| UniProt ID | ACM1_HUMAN | |||||
| Gene Name | CHRM1 | |||||
| Synonyms |
M1 receptor
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| Representative Drug(s) | Perhexiline | Drug Info | Ki = 652.8 nM | [1] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M3 (CHRM3) | Successful Target | ||||
| UniProt ID | ACM3_HUMAN | |||||
| Gene Name | CHRM3 | |||||
| Synonyms |
M3 receptor; CHRM3
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| Representative Drug(s) | Perhexiline | Drug Info | Ki = 661 nM | [1] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M5 (CHRM5) | Successful Target | ||||
| UniProt ID | ACM5_HUMAN | |||||
| Gene Name | CHRM5 | |||||
| Synonyms |
CHRM5
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| Representative Drug(s) | Perhexiline | Drug Info | Ki = 785.4 nM | [1] | ||
| Co-Target Name | Debrisoquine 4-hydroxylase (CYP2D6) | Successful Target | ||||
| UniProt ID | CP2D6_HUMAN | |||||
| Gene Name | CYP2D6 | |||||
| Synonyms |
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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| Representative Drug(s) | Perhexiline | Drug Info | IC50 = 940.8 nM | [1] | ||
| References | Top | ||||
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| REF 1 | DrugMatrix in vitro pharmacology data. National Toxicology Program | ||||
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