Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74437 | Target Info | |||
| Target Name | Actin polymerization (Actin poly) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Integrin alpha-L (ITGAL) | Successful Target | ||||
| UniProt ID | ITAL_HUMAN | |||||
| Gene Name | ITGAL | |||||
| Synonyms |
Lymphocyte Function-associated Antigen-1; Leukocyte function-associated molecule 1 alpha chain; Leukocyte function associated molecule 1, alpha chain; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; LFA-1; CD11a; CD11 antigen-like family member A
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| Representative Drug(s) | Preverex | Drug Info | IC50 = 5.5 ug.mL-1 | [1] | ||
| Co-Target Name | Intercellular adhesion molecule/Integrin alpha-L/Integrin beta-2 (ICAM1/ITGAL/ITGB2) | Co-Target | ||||
| UniProt ID | ICAM1_HUMAN-ITAL_HUMAN-ITB2_HUMAN | |||||
| Gene Name | ICAM1-ITGAL-ITGB2 | |||||
| Representative Drug(s) | Preverex | Drug Info | IC50 = 0.25 ug.mL-1 | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Antiparasitic alkaloids from Psychotria klugii. J Nat Prod. 2003 Jul;66(7):962-7. | ||||
| REF 2 | Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha. J Nat Prod. 2001 May;64(5):559-62. | ||||
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