Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T73992 Target Info
Target Name Beta-secretase (BACE)
Synonyms
Transmembrane aspartic protease; Beta-site amyloid precursor protein cleaving enzyme; Beta-site AbetaPP-cleaving enzyme; BACE1
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Target Type Clinical trial Target
Gene Name NO-GeName
Biochemical Class Peptidase
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Gamma-secretase (GS) Clinical trial Target
UniProt ID APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN
Gene Name APH1A; APH1B; NCSTN; PSENEN; PSEN1
Synonyms
Presenilin-stabilization factor-like; PSFL; Aph-1beta
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Representative Drug(s) RG7129 Drug Info IC50 = 30 nM [1]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) PMID23981898C11d Drug Info IC50 = 100 nM Click to Show More [2]
2 PMID23981898C11d Drug Info IC50 = 200 nM [2]
Co-Target Name Cathepsin D (CTSD) Clinical trial Target
UniProt ID CATD_HUMAN
Gene Name CTSD
Synonyms
CPSD; CD
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Representative Drug(s) PMID23981898C11d Drug Info IC50 = 820 nM [2]
References  Top
REF 1 Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-52.
REF 2 Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5300-6.

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