Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T73215 Target Info
Target Name Leukocyte surface antigen Leu-16 (CD20)
Synonyms
Membrane-spanning 4-domains subfamily A member 1; Leu-16; Bp35; B-lymphocyte surface antigen B1; B-lymphocyte antigen CD20
    Click to Show/Hide
Target Type Successful Target
Gene Name MS4A1
Biochemical Class CD20 calcium channel
UniProt ID
CD20_HUMAN
Co-Targets of This Target  Top
Co-Target Name Angiotensinogenase renin (REN) Successful Target
UniProt ID RENI_HUMAN
Gene Name REN
Synonyms
Renin; Angiotensinogenase
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info Ki = 100 nM [1]
Co-Target Name Cathepsin D (CTSD) Clinical trial Target
UniProt ID CATD_HUMAN
Gene Name CTSD
Synonyms
CPSD; CD
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 0.0016 ug.mL-1 [2]
Co-Target Name Cathepsin L (CTSL) Clinical trial Target
UniProt ID CATL1_HUMAN
Gene Name CTSL
Synonyms
Major excreted protein; MEP; Cathepsin L1; CTSL1
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 800 nM [3]
Co-Target Name Plasmodium Plasmepsin 2 (Malaria PLA2) Patented-recorded Target
UniProt ID PLM2_PLAFA
Gene Name Malaria PLA2
Synonyms
Plasmepsin-2; PFAPD; Aspartic hemoglobinase II
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 0.42 nM [4]
Co-Target Name Cathepsin E (CTSE) Literature-reported Target
UniProt ID CATE_HUMAN
Gene Name CTSE
Synonyms
Cathepsin E
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 0.08 nM [5]
Co-Target Name Plasmodium Plasmepsin 1 (Malaria PLA1) Literature-reported Target
UniProt ID PLM1_PLAFA
Gene Name Malaria PLA1
Synonyms
Plasmepsin I; PFAPG; Aspartic hemoglobinase I
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 0.9 nM [4]
Co-Target Name Pepsinogen-5 (PGA5) Literature-reported Target
UniProt ID PEPA5_HUMAN
Gene Name PGA5
Synonyms
Pepsin A-5
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 59 nM [6]
Co-Target Name Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) Co-Target
UniProt ID ADAM9_HUMAN
Gene Name ADAM9
Synonyms
ADAM 9; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase
    Click to Show/Hide
Representative Drug(s) Iboctadekin + rituximab Drug Info IC50 = 56.3 nM [7]
References  Top
REF 1 Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61.
REF 2 Inhibition of Cathepsin D protease activity by. Med Chem Res. 2012 Dec 18;22:3953-8.
REF 3 Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem. 2009 May 14;52(9):3093-7.
REF 4 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Bioorg Med Chem. 2018 May 15;26(9):2488-2500.
REF 5 Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium. Bioorg Med Chem. 2016 Aug 1;24(15):3276-82.
REF 6 Auxiliary agents for the peroral administration of peptide and protein drugs: synthesis and evaluation of novel pepstatin analogues. J Med Chem. 1998 Jun 18;41(13):2339-44.
REF 7 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.