Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72168 | Target Info | |||
| Target Name | Mineralocorticoid receptor (MR) | ||||
| Synonyms |
Nuclear receptor subfamily 3 group C member 2; Mineralocorticoid receptor; MLR; MCR; Inner ear mineralocorticoid receptor; Delta
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| Target Type | Successful Target | ||||
| Gene Name | NR3C2 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | ||||
| UniProt ID | GCR_HUMAN | |||||
| Gene Name | NR3C1 | |||||
| Synonyms |
Nuclear receptor subfamily 3 group C member 1; GRL; GR
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| Representative Drug(s) | Spironolactone | Drug Info | Ki = 32.6 nM | [1] | ||
| Co-Target Name | Androgen receptor (AR) | Successful Target | ||||
| UniProt ID | ANDR_HUMAN | |||||
| Gene Name | AR | |||||
| Synonyms |
Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR
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| Representative Drug(s) | Spironolactone | Drug Info | Ki = 39.4 nM | [1] | ||
| Co-Target Name | Progesterone receptor (PGR) | Successful Target | ||||
| UniProt ID | PRGR_HUMAN | |||||
| Gene Name | PGR | |||||
| Synonyms |
PR; Nuclear receptor subfamily 3 group C member 3; NR3C3
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| Representative Drug(s) | Spironolactone | Drug Info | Ki = 399.7 nM | [1] | ||
| Co-Target Name | Corticosteroid-binding globulin (SERPINA6) | Successful Target | ||||
| UniProt ID | CBG_HUMAN | |||||
| Gene Name | SERPINA6 | |||||
| Synonyms |
Transcortin; SERPINA6; CBG
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| Representative Drug(s) | Aldosterone | Drug Info | Ki = 524.81 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mine... J Med Chem. 2007 Dec 27;50(26):6443-5. | ||||
| REF 2 | Comparative molecular active site analysis (CoMASA). 1. An approach to rapid evaluation of 3D QSAR. J Med Chem. 2004 May 20;47(11):2732-42. | ||||
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