Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72065 | Target Info | |||
| Target Name | Voltage-gated sodium channel (Nav) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
| UniProt ID | CAH2_HUMAN | |||||
| Gene Name | CA2 | |||||
| Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 331 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase I (CA-I) | Successful Target | ||||
| UniProt ID | CAH1_HUMAN | |||||
| Gene Name | CA1 | |||||
| Synonyms |
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 362 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase VI (CA-VI) | Successful Target | ||||
| UniProt ID | CAH6_HUMAN | |||||
| Gene Name | CA6 | |||||
| Synonyms |
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 412 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase XIV (CA-XIV) | Successful Target | ||||
| UniProt ID | CAH14_HUMAN | |||||
| Gene Name | CA14 | |||||
| Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 473 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
| UniProt ID | CAH4_HUMAN | |||||
| Gene Name | CA4 | |||||
| Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 525 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
| UniProt ID | CAH9_HUMAN | |||||
| Gene Name | CA9 | |||||
| Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 353 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase VB (CA5B) | Co-Target | ||||
| UniProt ID | CAH5B_HUMAN | |||||
| Gene Name | CA5B | |||||
| Synonyms |
Carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA-VB
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 341 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase III (CA3) | Co-Target | ||||
| UniProt ID | CAH3_HUMAN | |||||
| Gene Name | CA3 | |||||
| Synonyms |
Carbonic anhydrase 3; Carbonate dehydratase III; CA-III
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| Representative Drug(s) | Lacosamide | Drug Info | Ki = 374 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem. 2010 Jan 28;53(2):850-4. | ||||
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