Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T71398 Target Info
Target Name Guanylate cyclase (GC)
Synonyms
Guanylyl Cyclase
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Target Type Successful Target
Gene Name NO-GeName
Biochemical Class Phosphorus-oxygen lyase
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Monoamine oxidase type A (MAO-A) Successful Target
UniProt ID AOFA_HUMAN
Gene Name MAOA
Synonyms
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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Representative Drug(s) Methylene blue Drug Info IC50 = 70 nM [1]
Co-Target Name Amyloid beta A4 protein (APP) Successful Target
UniProt ID A4_HUMAN
Gene Name APP
Synonyms
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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Representative Drug(s) Methylene blue Drug Info IC50 = 500 nM [2]
Co-Target Name Microtubule-associated protein tau (MAPT) Clinical trial Target
UniProt ID TAU_HUMAN
Gene Name MAPT
Synonyms
tau; Paired helical filamenttau; Paired helical filament-tau; Neurofibrillary tangle protein; MTBT1; MAPTL
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Representative Drug(s) Methylene blue Drug Info EC50 = 130 nM [3]
References  Top
REF 1 The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase. Eur J Med Chem. 2017 Jul 28;135:196-203.
REF 2 Design and synthesis of curcumin derivatives as tau and amyloid beta dual aggregation inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-8.
REF 3 Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. Eur J Med Chem. 2019 May 1;169:200-223.

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