Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71192 | Target Info | |||
| Target Name | Leukotriene CysLT1 receptor (CYSLTR1) | ||||
| Synonyms |
Leukotriene D4-receptor; LTD4 receptor; HMTMF81; HG55; G-protein coupled receptor HG55; Cysteinyl leukotriene receptor 1; Cysteinyl leukotriene D4 receptor; CysLTR1; CYSLT1
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| Target Type | Successful Target | ||||
| Gene Name | CYSLTR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Pregnane X receptor (NR1I2) | Literature-reported Target | ||||
| UniProt ID | NR1I2_HUMAN | |||||
| Gene Name | NR1I2 | |||||
| Synonyms |
Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
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| Representative Drug(s) | Zafirlukast | Drug Info | EC50 = 710 nM | [1] | ||
| Co-Target Name | Cytochrome P450 2C8 (CYP2C8) | Co-Target | ||||
| UniProt ID | CP2C8_HUMAN | |||||
| Gene Name | CYP2C8 | |||||
| Synonyms |
CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
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| Representative Drug(s) | Montelukast | Drug Info | IC50 = 1000 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos. 2011 Jan;39(1):151-9. | ||||
| REF 2 | Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. J Med Chem. 2018 Jan 11;61(1):224-250. | ||||
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