Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T66252 | Target Info | |||
Target Name | Dipeptidyl peptidase 9 (DPP-9) | ||||
Synonyms |
Dipeptidyl peptidase-like protein 9; Dipeptidyl peptidase IX; Dipeptidyl peptidase IV-related protein 2; DPRP2; DPRP-2; DPP IX; DPLP9; DP9
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Target Type | Clinical trial Target | ||||
Gene Name | DPP9 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Dipeptidyl peptidase 4 (DPP-4) | Successful Target | ||||
UniProt ID | DPP4_HUMAN | |||||
Gene Name | DPP4 | |||||
Synonyms |
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) | Talabostat | Drug Info | IC50 = 0.1 nM | [1] | ||
Co-Target Name | Dipeptidyl peptidase 8 (DPP-8) | Clinical trial Target | ||||
UniProt ID | DPP8_HUMAN | |||||
Gene Name | DPP8 | |||||
Synonyms |
Prolyl dipeptidase DPP8; MSTP141; MSTP135; MSTP097; Dipeptidyl peptidase VIII; Dipeptidyl peptidase IV-related protein 1; DPRP1; DPRP-1; DPP VIII; DP8
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Representative Drug(s) | Talabostat | Drug Info | Ki = 1.5 nM | [2] | ||
Co-Target Name | Prolyl endopeptidase FAP (FAP) | Clinical trial Target | ||||
UniProt ID | SEPR_HUMAN | |||||
Gene Name | FAP | |||||
Synonyms |
Integral membrane serine protease; Fibroblast activation protein alpha; FAP; Antiplasmin-cleaving enzyme; APCE; 170-kDa melanoma membrane-bound gelatinase
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Representative Drug(s) | Talabostat | Drug Info | IC50 = 12 nM | [3] | ||
Co-Target Name | Prolyl endopeptidase (PREP) | Clinical trial Target | ||||
UniProt ID | PPCE_HUMAN | |||||
Gene Name | PREP | |||||
Synonyms |
Post-proline cleaving enzyme; PREP; PE
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Representative Drug(s) | Talabostat | Drug Info | IC50 = 73 nM | [3] | ||
Co-Target Name | Dipeptidyl-peptidase 7 (DPP7) | Patented-recorded Target | ||||
UniProt ID | DPP2_HUMAN | |||||
Gene Name | DPP7 | |||||
Synonyms |
Quiescent cell proline dipeptidase; QPP; Dipeptidyl peptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; DPP2; DPP II
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Representative Drug(s) | Talabostat | Drug Info | IC50 = 15 nM | [4] |
References | Top | ||||
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REF 1 | Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10. | ||||
REF 2 | Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. | ||||
REF 3 | Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. | ||||
REF 4 | Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. J Med Chem. 1996 May 10;39(10):2087-94. |
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