Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T64410 Target Info
Target Name Bacterial DD-carboxypeptidase (Bact vanYB)
Synonyms
vanYB; DD-peptidase; DD-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase-transpeptidase
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Target Type Successful Target
Gene Name Bact vanYB
Biochemical Class Peptidase
UniProt ID
VANY_ENTFA
Co-Targets of This Target  Top
Co-Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target
UniProt ID PGH2_HUMAN
Gene Name PTGS2
Synonyms
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2
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Representative Drug(s) B-Lactams Drug Info IC50 = 2.5 ug.mL-1 [1]
Co-Target Name LCK tyrosine protein kinase (LCK) Successful Target
UniProt ID LCK_HUMAN
Gene Name LCK
Synonyms
p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn
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Representative Drug(s) B-Lactams Drug Info IC50 = 10 ug.mL-1 [2]
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) B-Lactams Drug Info Ki = 60.3 nM [3]
Co-Target Name Dipeptidyl peptidase 4 (DPP-4) Successful Target
UniProt ID DPP4_HUMAN
Gene Name DPP4
Synonyms
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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Representative Drug(s) B-Lactams Drug Info IC50 = 120 nM [4]
Co-Target Name Carbonic anhydrase IV (CA-IV) Successful Target
UniProt ID CAH4_HUMAN
Gene Name CA4
Synonyms
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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Representative Drug(s) B-Lactams Drug Info Ki = 293 nM [3]
Co-Target Name Xanthine dehydrogenase/oxidase (XDH) Successful Target
UniProt ID XDH_HUMAN
Gene Name XDH
Synonyms
Xanthine oxidase; Xanthine dehydrogenase; XDHA
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Representative Drug(s) B-Lactams Drug Info IC50 = 550 nM [5]
Co-Target Name Aldose reductase (AKR1B1) Successful Target
UniProt ID ALDR_HUMAN
Gene Name AKR1B1
Synonyms
Aldehyde reductase; AKR1B1
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Representative Drug(s) B-Lactams Drug Info IC50 = 600 nM [6]
Co-Target Name Glycogen synthase kinase-3 alpha (GSK-3A) Successful Target
UniProt ID GSK3A_HUMAN
Gene Name GSK3A
Synonyms
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
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Representative Drug(s) B-Lactams Drug Info IC50 = 800 nM [7]
Co-Target Name Fms-like tyrosine kinase 3 (FLT-3) Successful Target
UniProt ID FLT3_HUMAN
Gene Name FLT3
Synonyms
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135
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Representative Drug(s) B-Lactams Drug Info IC50 = 830 nM [8]
Co-Target Name Lysosomal alpha-glucosidase (GAA) Successful Target
UniProt ID LYAG_HUMAN
Gene Name GAA
Synonyms
GAA; Aglucosidase alfa; Acid maltase
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Representative Drug(s) B-Lactams Drug Info IC50 = 5.96 ug.mL-1 [9]
Co-Target Name Cytochrome P450 1B1 (CYP1B1) Clinical trial Target
UniProt ID CP1B1_HUMAN
Gene Name CYP1B1
Synonyms
CYPIB1
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Representative Drug(s) B-Lactams Drug Info Ki = 56 nM [10]
Co-Target Name Casein kinase II (CSNK2) Clinical trial Target
UniProt ID CSK21_HUMAN; CSK22_HUMAN; CSK23_HUMAN; CSK2B_HUMAN
Gene Name NO-GeName
Representative Drug(s) B-Lactams Drug Info IC50 = 500 nM Click to Show More [11]
2 B-Lactams Drug Info IC50 < 1000 nM [14]
Co-Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target
UniProt ID GSK3B_HUMAN
Gene Name GSK3B
Synonyms
Serine/threonine-protein kinase GSK3B; GSK-3 beta
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Representative Drug(s) B-Lactams Drug Info IC50 = 800 nM [7]
Co-Target Name NADPH oxidase 4 (NOX4) Clinical trial Target
UniProt ID NOX4_HUMAN
Gene Name NOX4
Synonyms
Renal NAD(P)Hoxidase; Renal NAD(P)H-oxidase; RENOX; Kidney superoxideproducing NADPH oxidase; Kidney superoxide-producing NADPH oxidase; Kidney oxidase1; Kidney oxidase-1; KOX1; KOX-1
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Representative Drug(s) B-Lactams Drug Info IC50 = 850 nM [12]
Co-Target Name Matrix metalloproteinase-12 (MMP-12) Clinical trial Target
UniProt ID MMP12_HUMAN
Gene Name MMP12
Synonyms
Macrophage metalloelastase; Macrophage elastase; MME; ME; HME
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Representative Drug(s) B-Lactams Drug Info IC50 = 980 nM [13]
Co-Target Name Carbonic anhydrase VII (CA-VII) Patented-recorded Target
UniProt ID CAH7_HUMAN
Gene Name CA7
Synonyms
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) B-Lactams Drug Info Ki = 4.7 nM [3]
Co-Target Name Cytochrome P450 1A1 (CYP1A1) Co-Target
UniProt ID CP1A1_HUMAN
Gene Name CYP1A1
Synonyms
CYPIA1; Hydroperoxy icosatetraenoate dehydratase; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1
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Representative Drug(s) B-Lactams Drug Info Ki = 890 nM [10]
References  Top
REF 1 Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002 Nov;65(11):1517-21.
REF 2 Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60.
REF 3 New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25.
REF 4 Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018 May 10;151:145-157.
REF 5 Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Nat Prod. 1998 Jan;61(1):71-6.
REF 6 Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4301-10.
REF 7 Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem. 2005 Feb 10;48(3):737-43.
REF 8 Flavonoids as receptor tyrosine kinase FLT3 inhibitors. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1768-70.
REF 9 Antioxidant and alpha-glucosidase inhibitory compounds from Pimpinella candolleana Wight et Arn. Med Chem Res. 2012 Jan 18;21:4324-9.
REF 10 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem. 2011 May 1;19(9):2842-9.
REF 11 A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs. Bioorg Med Chem. 2019 Mar 1;27(5):677-685.
REF 12 Small-molecule inhibitors of NADPH oxidase 4. J Med Chem. 2010 Sep 23;53(18):6758-62.
REF 13 Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg Med Chem. 2012 Jul 1;20(13):4164-71.
REF 14 Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids. J Med Chem. 2015 Sep 24;58(18):7400-8.

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