Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T62276 Target Info
Target Name Glutamate receptor ionotropic NMDA 1 (NMDAR1)
Synonyms NmethylDaspartate receptor subunit NR1; NMDR1; NMD-R1; N-methyl-D-aspartate receptor subunit NR1; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta1; Glutamate [NMDA] receptor subunit zeta-1; GluN1
Target Type Successful Target
Gene Name GRIN1
Biochemical Class Glutamate-gated ion channel
UniProt ID
NMDZ1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Glutamate receptor ionotropic NMDA 2B (NMDAR2B) Successful Target
UniProt ID NMDE2_HUMAN
Gene Name GRIN2B
Synonyms NR3; NR2B; NMDA receptor subunit 2B; NMDA receptor NR2B; NMDA NR2B receptor; N-methylD-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; HNR3; Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor NR2B subunit; Glutamate [NMDA] receptor subunit epsilon-2; GluN2B
Representative Drug(s) ELIPRODIL Drug Info Ki = 13 nM [1]
Co-Target Name Glutamate receptor AMPA 2 (GRIA2) Successful Target
UniProt ID GRIA2_HUMAN
Gene Name GRIA2
Synonyms Glutamate receptor ionotropic, AMPA 2; Glutamate receptor 2; GluRK2; GluRB; GluR2; GluR-K2; GluR-B; GluR-2; GluA2; AMPAselective glutamate receptor 2; AMPA-selective glutamate receptor 2
Representative Drug(s) NBQX Drug Info Ki = 210 nM [2]
Co-Target Name Glutamate receptor AMPA 4 (GRIA4) Successful Target
UniProt ID GRIA4_HUMAN
Gene Name GRIA4
Synonyms Glutamate receptor ionotropic, AMPA 4; GluRD; GluR4; GluA4; GRIA4; AMPAselective glutamate receptor 4
Representative Drug(s) NBQX Drug Info Ki = 600 nM [3]
Co-Target Name Glutamate receptor AMPA 3 (GRIA3) Successful Target
UniProt ID GRIA3_HUMAN
Gene Name GRIA3
Synonyms Glutamate receptor ionotropic, AMPA 3; GluRK3; GluRC; GluR3; GluA3; GRIA3; AMPAselective glutamate receptor 3
Representative Drug(s) NBQX Drug Info Ki = 900 nM [3]
Co-Target Name Glutamate receptor ionotropic (GRI) Clinical trial Target
UniProt ID GRIA1_HUMAN; GRIA2_HUMAN; GRIA3_HUMAN; GRIA4_HUMAN
Gene Name NO-GeName
Representative Drug(s) NBQX Drug Info IC50 = 52 nM [4]
References  Top
REF 1 Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5748-51.
REF 2 Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. J Med Chem. 2005 Jun 30;48(13):4200-3.
REF 3 Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine. J Med Chem. 2002 Sep 26;45(20):4383-6.
REF 4 Homology modeling of the ampa receptor: A quantitative predictive tool for the design of novel antagonists. Bioorg Med Chem Lett. 1997 Jun 3;7(11):1437-42.

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