Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T61339 Target Info
Target Name Alpha-glucosidase (GLA)
Synonyms
Maltase-glucoamylase; Maltase; Glucosidosucrase; Glucosidoinvertase; Glucoinvertase; Alpha-glucoside hydrolase; Alpha-glucopyranosidase; Alpha-D-glucoside glucohydrolase; Alpha-D-glucosidase; Alpha-1;4-glucosidase
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Target Type Successful Target
Gene Name GAA; GANAB; GANC
UniProt ID
LYAG_HUMAN; GANAB_HUMAN; GANC_HUMAN
Co-Targets of This Target  Top
Co-Target Name Intestinal maltase-glucoamylase (MGAM) Successful Target
UniProt ID MGA_HUMAN
Gene Name MGAM
Synonyms
MGAM
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Representative Drug(s) Deoxynojirimycin Drug Info IC50 = 40 nM [1]
Co-Target Name Lysosomal alpha-glucosidase (GAA) Successful Target
UniProt ID LYAG_HUMAN
Gene Name GAA
Synonyms
GAA; Aglucosidase alfa; Acid maltase
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Representative Drug(s) Deoxynojirimycin Drug Info IC50 = 60 nM [2]
Co-Target Name Neutral alpha-glucosidase AB (GANAB) Co-Target
UniProt ID GANAB_HUMAN
Gene Name GANAB
Synonyms
Glucosidase II subunit alpha; Alpha-glucosidase 2
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Representative Drug(s) Deoxynojirimycin Drug Info Ki = 14 nM [3]
References  Top
REF 1 Biological properties of D- and L-1-deoxyazasugars. J Med Chem. 2005 Mar 24;48(6):2036-44.
REF 2 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
REF 3 Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin. Bioorg. Med. Chem. Lett. 1992;2:27-32.

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