Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61033 | Target Info | |||
| Target Name | Ciliary neurotrophic factor receptor alpha (CNTFR) | ||||
| Synonyms |
Ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTFR alpha; CNTF receptor subunit alpha
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| Target Type | Clinical trial Target | ||||
| Gene Name | CNTFR | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Histamine H1 receptor (H1R) | Successful Target | ||||
| UniProt ID | HRH1_HUMAN | |||||
| Gene Name | HRH1 | |||||
| Synonyms |
HH1R; H1R
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| Representative Drug(s) | PegCNTF | Drug Info | IC50 = 100 nM | [1] | ||
| Co-Target Name | Platelet-activating factor receptor (PTAFR) | Successful Target | ||||
| UniProt ID | PTAFR_HUMAN | |||||
| Gene Name | PTAFR | |||||
| Synonyms |
PTAFR; PAF-R
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| Representative Drug(s) | PegCNTF | Drug Info | IC50 = 610 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. | ||||
| REF 2 | Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. J Med Chem. 1991 Jan;34(1):457-61. | ||||
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