Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60182 | Target Info | |||
| Target Name | Glucagon receptor (GCGR) | ||||
| Synonyms |
GLR; GL-R
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| Target Type | Successful Target | ||||
| Gene Name | GCGR | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Glucagon-like peptide 1 receptor (GLP1R) | Successful Target | ||||
| UniProt ID | GLP1R_HUMAN | |||||
| Gene Name | GLP1R | |||||
| Synonyms |
GLP-1R; GLP-1-R; GLP-1 receptor
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| Representative Drug(s) | Glucagon recombinant | Drug Info | EC50 = 0.0439 nM | [1] | ||
| Co-Target Name | Gastric inhibitory polypeptide receptor (GIPR) | Successful Target | ||||
| UniProt ID | GIPR_HUMAN | |||||
| Gene Name | GIPR | |||||
| Synonyms |
Glucosedependent insulinotropic polypeptide receptor; GIPR
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| Representative Drug(s) | Glucagon recombinant | Drug Info | EC50 ~ 1 10'8pM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists. J Med Chem. 2017 May 25;60(10):4293-303. | ||||
| REF 2 | Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. J Med Chem. 2018 Jul 12;61(13):5580-93. | ||||
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