Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59056 | Target Info | |||
| Target Name | Aldosterone synthase (CYP11B2) | ||||
| Synonyms |
Steroid 18hydroxylase; Cytochrome P450C18; Cytochrome P450Aldo; Cytochrome P450 11B2, mitochondrial; CYPXIB2; CYP11B2; Aldosteronesynthesizing enzyme; ALDOS
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| Target Type | Clinical trial Target | ||||
| Gene Name | CYP11B2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Steroid 11-beta-hydroxylase (CYP11B1) | Successful Target | ||||
| UniProt ID | C11B1_HUMAN | |||||
| Gene Name | CYP11B1 | |||||
| Synonyms |
S11BH; P450C11; P-450c11; CYPXIB1; CYP11B1
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| Representative Drug(s) | Osilodrostat | Drug Info | IC50 = 2.5 nM | [1] | ||
| Co-Target Name | Aromatase (CYP19A1) | Successful Target | ||||
| UniProt ID | CP19A_HUMAN | |||||
| Gene Name | CYP19A1 | |||||
| Synonyms |
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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| Representative Drug(s) | Osilodrostat | Drug Info | IC50 = 856 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects. J Med Chem. 2015 Dec 10;58(23):9382-94. | ||||
| REF 2 | Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. J Med Chem. 2014 Jun 26;57(12):5011-22. | ||||
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