Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55094 | Target Info | |||
| Target Name | Acid-sensing ion channel 1 (ASIC1) | ||||
| Synonyms |
Brain sodium channel 2; BNaC2; Amiloride-sensitive cation channel 2, neuronal; ASIC1; ACCN2
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | ASIC1 | ||||
| Biochemical Class | Amiloride-sensitive sodium channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Amiloride-sensitive sodium channel alpha (SCNN1A) | Co-Target | ||||
| UniProt ID | SCNNA_HUMAN | |||||
| Gene Name | SCNN1A | |||||
| Synonyms |
Amiloride-sensitive sodium channel subunit alpha; Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA
Click to Show/Hide
|
|||||
| Representative Drug(s) | Amiloride | Drug Info | IC50 = 776 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem. 2006 Jul 13;49(14):4098-115. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.