Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52316 | Target Info | |||
| Target Name | Raf messenger RNA (Raf mRNA) | ||||
| Synonyms |
cRaf (mRNA); Raf-1 (mRNA); RAF proto-oncogene serine/threonine-protein kinase (mRNA); RAF (mRNA)
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| Target Type | Clinical trial Target | ||||
| Gene Name | RAF1 | ||||
| Biochemical Class | mRNA target | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Serine/threonine-protein kinase B-raf (BRAF) | Successful Target | ||||
| UniProt ID | BRAF_HUMAN | |||||
| Gene Name | BRAF | |||||
| Synonyms |
V-Raf murine sarcoma viral oncogene homolog B1; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
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| Representative Drug(s) | LXH254 | Drug Info | IC50 = 0.4 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J Med Chem. 2020 Mar 12;63(5):2013-2027. | ||||
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