Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T50688 Target Info
Target Name Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)
Synonyms
Platelet membrane glycoprotein IIb; Platelet membrane glycoprotein IIIa; GP
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Target Type Successful Target
Gene Name ITGA2B; ITGB3
UniProt ID
ITA2B_HUMAN; ITB3_HUMAN
Co-Targets of This Target  Top
Co-Target Name Carbonic anhydrase II (CA-II) Successful Target
UniProt ID CAH2_HUMAN
Gene Name CA2
Synonyms
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) Hydroquinone Drug Info Ki = 90 nM [1]
Co-Target Name Integrin alpha-V/beta-3 (ITGAV/B3) Clinical trial Target
UniProt ID ITAV_HUMAN-ITB3_HUMAN
Gene Name ITGAV-ITGB3
Synonyms
Integrin alphaVbeta3; Integrin alpha-v beta-3; Integrin alpha V beta 3; Alpha(v)beta(3) Integrin; Alpha v beta 3 integrin
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Representative Drug(s) Tirofiban Drug Info IC50 ~ 1000 nM [2]
References  Top
REF 1 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
REF 2 Molecular model of the alpha(IIb)beta(3) integrin. J Med Chem. 2003 Dec 4;46(25):5316-25.

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