Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T49526 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv7.1 (KCNQ1) | ||||
| Synonyms |
Voltage-gated potassium channel subunit Kv7.1; Potassium voltage-gated channel subfamily KQT member 1; Kv7.1; KVLQT1; KQT-like 1; KCNQ1 channel; KCNA9; KCNA8; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1
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| Target Type | Successful Target | ||||
| Gene Name | KCNQ1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
| UniProt ID | CAH12_HUMAN | |||||
| Gene Name | CA12 | |||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 10 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase IV (CA-IV) | Successful Target | ||||
| UniProt ID | CAH4_HUMAN | |||||
| Gene Name | CA4 | |||||
| Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 213 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
| UniProt ID | CAH9_HUMAN | |||||
| Gene Name | CA9 | |||||
| Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 36 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
| UniProt ID | CAH7_HUMAN | |||||
| Gene Name | CA7 | |||||
| Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 0.23 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase VB (CA5B) | Co-Target | ||||
| UniProt ID | CAH5B_HUMAN | |||||
| Gene Name | CA5B | |||||
| Synonyms |
Carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA-VB
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 274 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase VA (CA5A) | Co-Target | ||||
| UniProt ID | CAH5A_HUMAN | |||||
| Gene Name | CA5A | |||||
| Synonyms |
Carbonic anhydrase 5A, mitochondrial; Carbonate dehydratase VA; CA-VA
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| Representative Drug(s) | Indapamide | Drug Info | Ki = 890 nM | [1] | ||
| References | Top | ||||
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| REF 1 | Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. | ||||
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