Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T48945 Target Info
Target Name TERT messenger RNA (TERT mRNA)
Synonyms
Telomerase-associated protein 2 (mRNA); Telomerase catalytic subunit (mRNA); TRT (mRNA); TP2 (mRNA); TCS1 (mRNA); HEST2 (mRNA); EST2 (mRNA)
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Target Type Successful Target
Gene Name TERT
Biochemical Class mRNA target
UniProt ID
TERT_HUMAN
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Doxorubicin Drug Info IC50 = 900 nM [1]
Co-Target Name Aurora kinase A (AURKA) Clinical trial Target
UniProt ID AURKA_HUMAN
Gene Name AURKA
Synonyms
hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK
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Representative Drug(s) Doxorubicin Drug Info IC50 = 40 nM [2]
Co-Target Name Hypoxia-inducible factor 2 alpha (HIF-2A) Successful Target
UniProt ID EPAS1_HUMAN
Gene Name EPAS1
Synonyms
bHLHe73; PASD2; PAS domain-containing protein 2; Member of PAS protein 2; MOP2; Hypoxia-inducible factor 2-alpha; HLF; HIF2A; HIF2-alpha; HIF-2-alpha; HIF-1-alpha-like factor; Endothelial PAS domain-containing protein 1; EPAS-1; Class E basic helix-loop-helix protein 73; Basic-helix-loop-helix-PAS protein MOP2
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Representative Drug(s) Doxorubicin Drug Info EC50 = 120 nM [3]
Co-Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target
UniProt ID HIF1A_HUMAN
Gene Name HIF1A
Synonyms
bHLHe78; Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; Member of PAS protein 1; MOP1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1 A; Hypoxia inducible factor 1; HIF1-alpha; HIF1 alpha; HIF-1alpha; HIF-1-alpha; HIF-1 alpha; Class E basic helix-loop-helix protein 78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
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Representative Drug(s) Doxorubicin Drug Info EC50 = 120 nM [3]
Co-Target Name DNA topoisomerase II alpha (TOP2A) Clinical trial Target
UniProt ID TOP2A_HUMAN
Gene Name TOP2A
Synonyms
DNA topoisomerase II, alpha isozyme; DNA topoisomerase 2alpha; DNA topoisomerase 2-alpha
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Representative Drug(s) Doxorubicin Drug Info IC50 = 600 nM [4]
References  Top
REF 1 Developing a dynamic pharmacophore model for HIV-1 integrase. J Med Chem. 2000 Jun 1;43(11):2100-14.
REF 2 Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3690-5.
REF 3 Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii. J Nat Prod. 2009 May 22;72(5):805-12.
REF 4 Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. J Med Chem. 2019 Mar 28;62(6):2950-2973.

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