Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48940 | Target Info | |||
| Target Name | HIF-prolyl hydroxylase (HPH) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | HIF-prolyl hydroxylase 2 (HPH-2) | Patented-recorded Target | ||||
| UniProt ID | EGLN1_HUMAN | |||||
| Gene Name | EGLN1 | |||||
| Synonyms |
SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12
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| Representative Drug(s) | AKB-6548 | Drug Info | IC50 = 29 nM | Click to Show More | [1] | |
| 2 | FG-2216 | Drug Info | IC50 = 70 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem. 2019 Jun 15;27(12):2405-2412. | ||||
| REF 2 | Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem. 2013 Jan 24;56(2):547-55. | ||||
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