Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43415 | Target Info | |||
| Target Name | Tyrosine-protein kinase (PTK) | ||||
| Synonyms |
Protein-tyrosine kinase; PTK
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | ||||
| UniProt ID | EGFR_HUMAN | |||||
| Gene Name | EGFR | |||||
| Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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| Representative Drug(s) | KD019 | Drug Info | IC50 = 0.3 nM | [1] | ||
| Co-Target Name | Tyrosine protein kinase JAK1-Non receptor tyrosine protein kinase TYK2 (JAK1-TYK2) | Co-Target | ||||
| UniProt ID | JAK1_HUMAN-TYK2_HUMAN | |||||
| Gene Name | JAK1-TYK2 | |||||
| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 15 nM | Click to Show More | [2] | |
| 2 | Abrocitinib | Drug Info | IC50 = 189 nM | [4] | ||
| Co-Target Name | JAK1-JAK2-TYK2 complex (JAK1-JAK2-TYK2) | Co-Target | ||||
| UniProt ID | JAK1_HUMAN-JAK2_HUMAN-TYK2_HUMAN | |||||
| Gene Name | JAK1-JAK2-TYK2 | |||||
| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 16 nM | Click to Show More | [2] | |
| 2 | Abrocitinib | Drug Info | IC50 = 163 nM | [4] | ||
| Co-Target Name | Tyrosine protein kinase JAK1-Tyrosine protein kinase JAK3 complex (JAK1-JAK3) | Co-Target | ||||
| UniProt ID | JAK3_HUMAN-JAK1_HUMAN | |||||
| Gene Name | JAK1-JAK3 | |||||
| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 67 nM | Click to Show More | [2] | |
| 2 | Abrocitinib | Drug Info | IC50 = 511 nM | [4] | ||
| Co-Target Name | Tyrosine protein kinase JAK2-Non receptor tyrosine protein kinase TYK2 complex (JAK2-TYK2) | Co-Target | ||||
| UniProt ID | JAK2_HUMAN-TYK2_HUMAN | |||||
| Gene Name | JAK2-TYK2 | |||||
| Representative Drug(s) | Baricitinib | Drug Info | IC50 = 81.9 nM | [3] | ||
| Co-Target Name | Tyrosine protein kinase JAK1-Tyrosine protein kinase JAK2 complex (JAK1-JAK2) | Co-Target | ||||
| UniProt ID | JAK1_HUMAN-JAK2_HUMAN | |||||
| Gene Name | JAK2-JAK1 | |||||
| Representative Drug(s) | Abrocitinib | Drug Info | IC50 = 163 nM | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma. J Med Chem. 2019 May 9;62(9):4772-4778. | ||||
| REF 2 | Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J Med Chem. 2016 Jan 28;59(2):733-49. | ||||
| REF 3 | Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem. 2014 Jun 26;57(12):5023-38. | ||||
| REF 4 | Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152. | ||||
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