Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T42724 Target Info
Target Name Calcium-activated potassium channel KCa3.1 (KCNN4)
Synonyms SKCa4; SKCa 4; SK4; Putative Gardos channel; KCa4; KCa3.1; Intermediate conductance calcium-activated potassium channel protein 4; IKCa1; IK1
Target Type Clinical trial Target
Gene Name KCNN4
Biochemical Class Voltage-gated ion channel
UniProt ID
KCNN4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Voltage-gated potassium channel Kv1.5 (KCNA5) Successful Target
UniProt ID KCNA5_HUMAN
Gene Name KCNA5
Synonyms Voltage-gatedpotassium channel subunit Kv1.5; Voltage-gated potassium channel subunit Kv1.5; Voltage-gated potassium channel HK2; Potassium voltage-gated channel subfamily A member 5; Potassium channel Kv1.5; HPCN1; HK2; 02-Sensitive Potassium Channel Kv1.5
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated potassium channel Kv7.1 (KCNQ1) Successful Target
UniProt ID KCNQ1_HUMAN
Gene Name KCNQ1
Synonyms Voltage-gated potassium channel subunit Kv7.1; Potassium voltage-gated channel subfamily KQT member 1; Kv7.1; KVLQT1; KQT-like 1; KCNQ1 channel; KCNA9; KCNA8; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated sodium channel alpha Nav1.3 (SCN3A) Successful Target
UniProt ID SCN3A_HUMAN
Gene Name SCN3A
Synonyms Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subtype III; Sodium channel protein, brain III subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein brain III subunit alpha; NAC3; KIAA1356
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated sodium channel alpha Nav1.4 (SCN4A) Clinical trial Target
UniProt ID SCN4A_HUMAN
Gene Name SCN4A
Synonyms Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein type IV subunit alpha; Sodium channel protein skeletal muscle subunit alpha; SkM1; SCN4A
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated sodium channel alpha Nav1.6 (SCN8A) Clinical trial Target
UniProt ID SCN8A_HUMAN
Gene Name SCN8A
Synonyms Voltage-gated sodium channel subunit alpha Nav1.6; Sodium channel protein type VIII subunit alpha; Sodium channel protein type 8 subunit alpha; SCN8A
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated sodium channel alpha Nav1.7 (SCN9A) Clinical trial Target
UniProt ID SCN9A_HUMAN
Gene Name SCN9A
Synonyms hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Voltage-gated sodium channel alpha Nav1.2 (SCN2A) Literature-reported Target
UniProt ID SCN2A_HUMAN
Gene Name SCN2A
Synonyms Voltage-gated sodium channelsubunit alpha Nav1.2; Sodium channel protein type II subunit alpha; Sodium channel protein brainII subunit alpha; SCN2A; HBSC II
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Protein Red (IK) Co-Target
UniProt ID RED_HUMAN
Gene Name IK
Synonyms Cytokine IK; IK factor; Protein RER
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
Co-Target Name Sodium channel protein type I alpha (SCN1A) Co-Target
UniProt ID SCN1A_HUMAN
Gene Name SCN1A
Synonyms Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1
Representative Drug(s) ICA-17043 Drug Info IC50 ~ 1000 nM [1]
References  Top
REF 1 Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem. 2013 Feb 14;56(3):593-624.

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