Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39087 | Target Info | |||
| Target Name | Human immunodeficiency virus Integrase (HIV IN) | ||||
| Synonyms |
HIV IN
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | HIV IN | ||||
| Biochemical Class | Integrase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV RT | |||||
| Synonyms |
HIV p66 RT; HIV Exoribonuclease H
Click to Show/Hide
|
|||||
| Representative Drug(s) | S-1360 | Drug Info | IC50 = 20 nM | [1] | ||
| Co-Target Name | C-C chemokine receptor type 1 (CCR1) | Clinical trial Target | ||||
| UniProt ID | CCR1_HUMAN | |||||
| Gene Name | CCR1 | |||||
| Synonyms |
SCYAR1; RANTES-R; Macrophage inflammatory protein-1 alpha receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; LD78 receptor; HM145; Chemokine receptor CCR1; CMKR1; CMKBR1; CD191; CCR-1; CC-CKR-1; C-C CKR-1
Click to Show/Hide
|
|||||
| Representative Drug(s) | Raltegravir | Drug Info | Ki = 5 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors. J Med Chem. 2005 Jan 13;48(1):111-20. | ||||
| REF 2 | Chemokine receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9363-92. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.