Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T39078 | Target Info | |||
| Target Name | Calcium-activated potassium channel (KCN) | ||||
| Synonyms |
Ca-activated K channel
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | ||||
| UniProt ID | KCNH2_HUMAN | |||||
| Gene Name | KCNH2 | |||||
| Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Voltage-gated sodium channel alpha Nav1.3 (SCN3A) | Successful Target | ||||
| UniProt ID | SCN3A_HUMAN | |||||
| Gene Name | SCN3A | |||||
| Synonyms |
Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subtype III; Sodium channel protein, brain III subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein brain III subunit alpha; NAC3; KIAA1356
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Voltage-gated sodium channel alpha Nav1.4 (SCN4A) | Clinical trial Target | ||||
| UniProt ID | SCN4A_HUMAN | |||||
| Gene Name | SCN4A | |||||
| Synonyms |
Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein type IV subunit alpha; Sodium channel protein skeletal muscle subunit alpha; SkM1; SCN4A
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Voltage-gated sodium channel alpha Nav1.6 (SCN8A) | Clinical trial Target | ||||
| UniProt ID | SCN8A_HUMAN | |||||
| Gene Name | SCN8A | |||||
| Synonyms |
Voltage-gated sodium channel subunit alpha Nav1.6; Sodium channel protein type VIII subunit alpha; Sodium channel protein type 8 subunit alpha; SCN8A
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | Clinical trial Target | ||||
| UniProt ID | SCN9A_HUMAN | |||||
| Gene Name | SCN9A | |||||
| Synonyms |
hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Voltage-gated sodium channel alpha Nav1.2 (SCN2A) | Literature-reported Target | ||||
| UniProt ID | SCN2A_HUMAN | |||||
| Gene Name | SCN2A | |||||
| Synonyms |
Voltage-gated sodium channelsubunit alpha Nav1.2; Sodium channel protein type II subunit alpha; Sodium channel protein brainII subunit alpha; SCN2A; HBSC II
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Protein Red (IK) | Co-Target | ||||
| UniProt ID | RED_HUMAN | |||||
| Gene Name | IK | |||||
| Synonyms |
Cytokine IK; IK factor; Protein RER
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Sodium channel protein type I alpha (SCN1A) | Co-Target | ||||
| UniProt ID | SCN1A_HUMAN | |||||
| Gene Name | SCN1A | |||||
| Synonyms |
Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1
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| Representative Drug(s) | ICA-17043 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| References | Top | ||||
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| REF 1 | Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem. 2013 Feb 14;56(3):593-624. | ||||
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