Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37847 | Target Info | |||
| Target Name | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | ||||
| Synonyms |
HSV DNA polymerase catalytic subunit
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| Target Type | Successful Target | ||||
| Gene Name | HSV UL30 | ||||
| Biochemical Class | DNA polymerase type-B | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Thymidine kinase 1 (TK1) | Successful Target | ||||
| UniProt ID | KITH_HUMAN | |||||
| Gene Name | TK1 | |||||
| Synonyms |
Thymidine kinase, cytosolic
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| Representative Drug(s) | Fialuridine | Drug Info | Ki = 140 nM | [1] | ||
| Co-Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | ||||
| UniProt ID | MDM2_HUMAN | |||||
| Gene Name | MDM2 | |||||
| Synonyms |
RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
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| Representative Drug(s) | Cytarabine | Drug Info | IC50 = 20 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71. | ||||
| REF 2 | The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy. Eur J Med Chem. 2018 Nov 5;159:1-9. | ||||
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