Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30520 | Target Info | |||
| Target Name | Bacterial RNA polymerase switch region (Bact RNAP-SR) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Pregnane X receptor (NR1I2) | Literature-reported Target | ||||
| UniProt ID | NR1I2_HUMAN | |||||
| Gene Name | NR1I2 | |||||
| Synonyms |
Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
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| Representative Drug(s) | Rifampin | Drug Info | EC50 = 190 nM | [1] | ||
| Co-Target Name | Liver organic anion transporter 1 (SLCO1B1) | Literature-reported Target | ||||
| UniProt ID | SO1B1_HUMAN | |||||
| Gene Name | SLCO1B1 | |||||
| Synonyms |
Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; SLC21A6; OATPC; OATP2; OATP-C; OATP-2; Liver-specific organic anion transporter 1; LST1; LST-1
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| Representative Drug(s) | Rifampin | Drug Info | IC50 = 300 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. J Med Chem. 2016 May 26;59(10):4601-10. | ||||
| REF 2 | The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery. Drug Metab Dispos. 2012 Aug;40(8):1641-8. | ||||
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