Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27861 | Target Info | |||
| Target Name | Protein cereblon (CRBN) | ||||
| Synonyms |
Protein cereblon
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| Target Type | Clinical trial Target | ||||
| Gene Name | CRBN | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Protein cereblon-Zinc finger protein Aiolos complex (CRBN-IKZF3) | Co-Target | ||||
| UniProt ID | CRBN_HUMAN-IKZF3_HUMAN | |||||
| Gene Name | CRBN-IKZF3 | |||||
| Representative Drug(s) | CC-220 | Drug Info | EC50 = 0.5 nM | [1] | ||
| Co-Target Name | Protein cereblon-DNA-binding protein Ikaros (CRBN-IKZF1) | Co-Target | ||||
| UniProt ID | CRBN_HUMAN-IKZF1_HUMAN | |||||
| Gene Name | CRBN-IKZF1 | |||||
| Representative Drug(s) | CC-220 | Drug Info | EC50 = 1 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J Med Chem. 2018 Jan 25;61(2):535-542. | ||||
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